Description

o-Desmethyl Venlafaxine Dimer CAS NO 1187545-62-5 is a high-purity synthetic intermediate of significant importance in advanced pharmaceutical research and development. This compound serves as a critical building block for the synthesis and analytical characterization of novel active pharmaceutical ingredients (APIs). It is primarily required by pharmaceutical manufacturers, contract research organizations (CROs), and analytical laboratories engaged in the development of next-generation therapeutics.

Application

• Pharmaceutical Reference Standard: Used as a certified reference material (CRM) for the qualitative and quantitative analysis of drug substances and products in quality control laboratories.
• Metabolite Synthesis: Acts as a key intermediate in the chemical synthesis of drug metabolites for pharmacokinetic and toxicological studies.
• Process Impurity Standard: Essential for the identification, monitoring, and control of dimeric impurities during the active pharmaceutical ingredient (API) manufacturing process.
• Analytical Method Development: Employed in the development and validation of high-performance liquid chromatography (HPLC) and mass spectrometry (MS) methods for complex pharmaceutical matrices.
• Regulatory Compliance: Supports regulatory filings (e.g., FDA, EMA) by providing well-characterized impurities and degradation products for stability studies and method validation.
• Research Chemical: Utilized in academic and industrial research settings for studying structure-activity relationships (SAR) and metabolic pathways.

Basic Information

Product Name	o-Desmethyl Venlafaxine Dimer
CAS No.	1187545-62-5
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	Desvenlafaxine Dimer; O-Didesmethyl Venlafaxine Dimer; ODV Dimer; N,N-Didesmethylvenlafaxine Dimer; (R/S)-O-Desmethylvenlafaxine Dimer; Major Human Metabolite of Venlafaxine Dimer; Pristiq Related Compound Dimer
EINECS	Contact for details

Quality Control

Our o-Desmethyl Venlafaxine Dimer is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods, to ensure it meets the stringent requirements for pharmaceutical reference standards and advanced intermediates. A comprehensive Certificate of Analysis (COA) detailing purity, impurities, and test results is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (typically 15-25°C). The product is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Individual impurity: ≤ 0.5% Total impurities: ≤ 2.0%
Residual Solvents (GC)	Complies with ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.