Description

(R)-2-(4-Fluorophenyl)Piperidine CAS NO 1187468-22-9 is a high-purity chiral piperidine derivative, a critical building block in modern pharmaceutical research and development. Its value lies in its role as a versatile intermediate for constructing complex molecules with specific stereochemistry, essential for creating active pharmaceutical ingredients (APIs) with targeted therapeutic effects. This compound is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and fine chemical industries for applications in asymmetric synthesis and medicinal chemistry programs.

Application

• Pharmaceutical Intermediate: Key chiral synthon for the research and development of novel central nervous system (CNS) active drugs, receptor modulators, and other bioactive molecules.
• Asymmetric Synthesis: Used as a chiral ligand precursor or a resolved amine building block in catalytic and stoichiometric asymmetric transformations.
• Medicinal Chemistry & SAR Studies: Employed in structure-activity relationship (SAR) studies to explore the impact of the (R)-configured fluorophenyl-piperidine moiety on potency and selectivity.
• Agrochemical Research: Serves as an intermediate in the synthesis of advanced crop protection agents and pesticides requiring specific stereochemistry.
• Fine Chemical Synthesis: A valuable precursor for custom synthesis and the manufacture of specialty chemicals where optical purity is paramount.
• Reference Standard: Used as an analytical standard for quality control and method development in chiral analysis (e.g., chiral HPLC).

Basic Information

Product Name	(R)-2-(4-Fluorophenyl)Piperidine
CAS No.	1187468-22-9
Molecular Formula	C11H14FN
Molecular Weight	179.24 g/mol
Synonyms	(R)-2-(4-Fluorophenyl)piperidine; (R)-2-(p-Fluorophenyl)piperidine; (2R)-2-(4-Fluorophenyl)piperidine; (R)-4-Fluoro-α-piperidinobenzyl; (R)-α-(4-Fluorophenyl)piperidine; (R)-2-(4-Fluorophenyl)piperidine hydrochloride (salt form); (R)-FPIP; (R)-FPP
EINECS	Contact for details

Quality Control

Our (R)-2-(4-Fluorophenyl)Piperidine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral HPLC for enantiomeric excess (ee) and standard purity assays, to ensure it meets the high standards required for research and development. Certificates of Analysis (COA) detailing identity, purity, chiral purity, and impurity profiles are available upon request to support your regulatory and quality documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation from moisture absorption.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.