Description

Cyclohexaneacetic Acid, α-[[(1,1-Dimethylethoxy)Carbonyl]Amino]-4-Methyl-, trans-(αs)- is a high-purity, stereochemically defined chiral intermediate of significant value in advanced organic synthesis. Its core value proposition lies in its role as a sophisticated building block for constructing complex molecules with precise spatial orientation, which is critical for developing active pharmaceutical ingredients (APIs) and other fine chemicals. This compound is essential for research and development chemists in the pharmaceutical, agrochemical, and specialty chemical industries who require reliable, high-quality intermediates for asymmetric synthesis and process development.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and production of novel therapeutic agents, particularly for central nervous system (CNS) and anti-inflammatory drugs.
• Agrochemical Synthesis: Used in the development of advanced, enantiomerically pure pesticides and herbicides where specific stereochemistry impacts biological activity.
• Peptidomimetics & Prodrug Design: Serves as a constrained, non-natural amino acid analog for creating stable peptide-like structures and designing targeted prodrugs.
• Catalyst & Ligand Development: Acts as a precursor for synthesizing novel chiral ligands and organocatalysts used in asymmetric catalysis.
• Academic & Industrial R&D: A valuable tool for method development in stereoselective synthesis and exploring new chemical spaces in medicinal chemistry programs.
• Fine Chemical Production: Employed in the multistep synthesis of complex fragrance ingredients, flavors, and other high-value specialty chemicals.

Basic Information

Item	Detail
Product Name	Cyclohexaneacetic Acid, α-[[(1,1-Dimethylethoxy)Carbonyl]Amino]-4-Methyl-, trans-(αs)-
CAS No.	1187224-06-1
Molecular Formula	C14H25NO4
Molecular Weight	271.35 g/mol
Synonyms	trans-(αs)-α-[(tert-Butoxycarbonyl)amino]-4-methylcyclohexaneacetic acid; (1R,4S)-4-Methyl-2-[(tert-butoxycarbonyl)amino]cyclohexaneacetic acid; Boc-4-methyl-D-cyclohexylglycine; (1R,4S)-Boc-NH-4-Me-Chg-OH; tert-Butyl ((1R,4S)-4-methyl-2-(carboxymethyl)cyclohexyl)carbamate; trans-4-Methyl-Boc-cyclohexylglycine; A chiral cyclohexylglycine derivative
EINECS	Contact for details

Quality Control

Every batch of our Cyclohexaneacetic Acid, α-[[(1,1-Dimethylethoxy)Carbonyl]Amino]-4-Methyl-, trans-(αs)- is produced under strict quality management systems. We employ advanced analytical techniques including HPLC, chiral HPLC, GC, and NMR to ensure identity, purity, and enantiomeric excess meet the stringent requirements of our clients. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with each shipment, and custom purity grades (e.g., >98%, >99%) are available to support your specific project needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); therefore, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.