Description

tert-Butyl 4,4-Difluoro-3-Hydroxypiperidine-1-Carboxylate is a high-value, multi-functional piperidine derivative that serves as a critical building block in advanced organic synthesis. This compound is essential for medicinal chemistry research and development, offering a versatile scaffold for constructing complex molecules with potential biological activity. It is primarily utilized by pharmaceutical R&D teams and fine chemical manufacturers focused on developing new active pharmaceutical ingredients (APIs), particularly in areas requiring fluorinated and hydroxylated heterocycles.

Application

• Pharmaceutical Intermediate: A key synthon in the research and synthesis of novel drug candidates, especially for central nervous system (CNS) and metabolic disease targets.
• Medicinal Chemistry Building Block: Used to introduce the 4,4-difluoro-3-hydroxypiperidine moiety, a privileged structure that can enhance metabolic stability, bioavailability, and target binding affinity.
• Agrochemical Research: Employed in the development of new generation pesticides and herbicides, where the difluorinated piperidine structure can contribute to improved efficacy and environmental profile.
• Ligand and Catalyst Development: Serves as a precursor for chiral ligands or organocatalysts used in asymmetric synthesis.
• Chemical Biology Probes: Utilized in the design and synthesis of molecular probes for studying enzyme function and biological pathways.
• Custom Synthesis and Contract Manufacturing: A critical starting material for custom synthesis projects and scale-up campaigns under cGMP or ISO standards.

Basic Information

Product Name	tert-Butyl 4,4-Difluoro-3-Hydroxypiperidine-1-Carboxylate
CAS No.	1186688-52-7
Molecular Formula	C10H17F2NO3
Molecular Weight	237.25 g/mol
Synonyms	1-Boc-4,4-difluoro-3-hydroxypiperidine; 1-(tert-Butoxycarbonyl)-4,4-difluoro-3-hydroxypiperidine; 4,4-Difluoro-3-hydroxy-1-piperidinecarboxylic acid tert-butyl ester; tert-Butyl 4,4-difluoro-3-hydroxy-1-piperidinecarboxylate; 3-Hydroxy-4,4-difluoropiperidine-1-carboxylic acid tert-butyl ester; 1-N-Boc-4,4-difluoro-3-hydroxypiperidine; Boc-4,4-difluoro-3-hydroxypiperidine
EINECS	Contact for details

Quality Control

Our tert-Butyl 4,4-Difluoro-3-Hydroxypiperidine-1-Carboxylate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes. Our production can align with cGMP guidelines for pharmaceutical applications, and we support audits and regulatory documentation as required.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after opening to prevent moisture absorption, which may affect stability and performance. For long-term storage, consider using desiccants or storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.