Description

5-Nitro-6-(Trifluoromethyl)-1H-Indole is a high-value, multi-functional heterocyclic building block characterized by its indole core substituted with both nitro and trifluoromethyl groups. This unique molecular architecture makes it a critical intermediate for the synthesis of advanced pharmaceuticals and agrochemicals, where it imparts desirable biological activity and metabolic stability. It is primarily sought after by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and advanced material sectors for constructing novel active compounds.

Application

• Pharmaceutical Intermediate: A key synthon for the development of novel drug candidates, particularly in oncology, CNS disorders, and anti-inflammatory therapies.
• Agrochemical Synthesis: Used in the research and production of next-generation herbicides, fungicides, and insecticides, leveraging the bioactivity of the indole and trifluoromethyl motifs.
• Material Science Research: Serves as a precursor for functional organic materials, including organic light-emitting diodes (OLEDs) and conductive polymers.
• Chemical Biology & Proteomics: Employed as a molecular scaffold or tag in the design of chemical probes and enzyme inhibitors for biological pathway studies.
• Academic & Contract Research: Essential for methodological development and discovery chemistry in university and CRO (Contract Research Organization) laboratories.

Basic Information

Item	Details
Product Name	5-Nitro-6-(Trifluoromethyl)-1H-Indole
CAS No.	1186405-05-9
Molecular Formula	C9H5F3N2O2
Molecular Weight	230.15 g/mol
Synonyms	5-Nitro-6-(trifluoromethyl)-1H-indole; 6-(Trifluoromethyl)-5-nitro-1H-indole; 1H-Indole, 5-nitro-6-(trifluoromethyl)-; 5-Nitro-6-trifluoromethylindole; 1186405-05-9; 5-Nitro-6-trifluoromethyl-1H-indole; 6-Trifluoromethyl-5-nitroindole
EINECS	Contact for details

Quality Control

Every batch of 5-Nitro-6-(Trifluoromethyl)-1H-Indole is manufactured and tested under a strict quality management system. We provide comprehensive analytical data to ensure the compound meets the high-purity standards required for research and development. A detailed Certificate of Analysis (COA) confirming identity, purity, and impurity profile via HPLC, NMR, and MS is available for each lot upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at room temperature (15-25°C). Keep away from incompatible materials such as strong oxidizing agents. Due to its light-sensitive nature, prolonged exposure to light should be avoided.

Specification

Item	Specification
Appearance	Yellow to brown powder or crystalline solid
Identification (HPLC/MS)	Conforms
Purity (HPLC)	≥97.0% (Standard Grade)
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.