Description

n-(Piperidin-1-Yl)-5-(4-(4-(3-(5-Carboxamidotetramethylrhodaminyl)Propyl))Phenyl)-1-(2,4-Dichlorophenyl)-4-Methyl-1H-Pyrazole-3-Carboxamide is a sophisticated, high-purity chemical building block designed for advanced research and development. This compound is critical for the synthesis of novel fluorescent probes and diagnostic agents due to its integrated tetramethylrhodamine (TAMRA) fluorophore. It is primarily utilized by pharmaceutical R&D teams, biotechnology companies, and academic research institutions focused on molecular imaging, assay development, and targeted drug discovery.

Application

• Fluorescent Probe Synthesis: A key intermediate for creating highly specific fluorescent labels for cellular and molecular imaging.
• Diagnostic Reagent Development: Used in the research and production of reagents for in vitro diagnostics (IVD) and bioassays.
• Bioconjugation: Serves as a reactive moiety for labeling antibodies, peptides, proteins, and oligonucleotides with a bright, photostable TAMRA dye.
• High-Throughput Screening (HTS): Integral to developing fluorescent tracers and sensors for drug discovery screening platforms.
• Molecular Biology Research: Enables fluorescence in situ hybridization (FISH) and other advanced microscopy techniques.
• Chemical Biology Tool Development: Used to create activity-based probes for studying enzyme function and protein interactions.

Basic Information

Product Name	n-(Piperidin-1-Yl)-5-(4-(4-(3-(5-Carboxamidotetramethylrhodaminyl)Propyl))Phenyl)-1-(2,4-Dichlorophenyl)-4-Methyl-1H-Pyrazole-3-Carboxamide
CAS No.	1186195-59-4
Molecular Formula	C51H52Cl2N6O4
Molecular Weight	899.91 g/mol
Synonyms	5-TAMRA-PP-Pyrazole-Carboxamide; TAMRA-Labeled Pyrazole Derivative; 1-(2,4-Dichlorophenyl)-4-methyl-N-(piperidin-1-yl)-5-[4-[4-[3-[(5-carbamoyl-9-(dimethylamino)-2,7-dichloro-10-phenyl-5H-benzo[a]phenoxazin-3-yl)oxy]propyl]phenyl]-1H-pyrazole-3-carboxamide; 5-Carboxytetramethylrhodamine Conjugate; Rhodamine 6G derivative; Fluorescent Pyrazole Probe; CAS 1186195-59-4
EINECS	Contact for details

Quality Control

Our n-(Piperidin-1-Yl)-5-(4-(4-(3-(5-Carboxamidotetramethylrhodaminyl)Propyl))Phenyl)-1-(2,4-Dichlorophenyl)-4-Methyl-1H-Pyrazole-3-Carboxamide is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and spectrophotometry for fluorophore performance. Certificates of Analysis (COA) detailing all specifications are provided to ensure traceability and compliance with your research-grade requirements.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a desiccated environment. This compound is hygroscopic (moisture-sensitive) and light-sensitive. For long-term storage, keep under an inert atmosphere such as argon or nitrogen. Allow the sealed container to equilibrate to room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	Red to purple solid or powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95% (Area Percent)
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines
Fluorescence Properties	λex/λem ~540 nm / ~568 nm (solvent dependent)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.