Description

4,4-Difluoro-1-Methylpiperidine is a high-value, fluorinated piperidine derivative, serving as a critical building block in advanced organic synthesis. Its unique structure, featuring two fluorine atoms at the 4-position, is essential for modulating the physicochemical and metabolic properties of target molecules. This compound is primarily utilized by research chemists and process development scientists in the pharmaceutical and agrochemical industries for the development of novel active ingredients.

Application

• Pharmaceutical Intermediate: A key synthon in the research and development of new drug candidates, particularly for introducing fluorine to enhance bioavailability and metabolic stability.
• Agrochemical Synthesis: Used in creating advanced pesticides and herbicides where the difluoropiperidine moiety can improve activity and environmental profile.
• Ligand & Catalyst Development: Serves as a precursor for nitrogen-containing ligands used in asymmetric catalysis and metal-organic frameworks (MOFs).
• Material Science Research: Employed in the synthesis of specialty polymers and functional materials that require fluorinated amine components.
• Chemical Biology Probes: Useful for labeling and modifying biomolecules in proteomics and diagnostic assay development.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs for the production of complex molecules under cGMP or research-grade conditions.

Basic Information

Product Name	4,4-Difluoro-1-Methylpiperidine
CAS No.	1186194-60-4
Molecular Formula	C6H11F2N
Molecular Weight	135.16 g/mol
Synonyms	1-Methyl-4,4-difluoropiperidine; 4,4-Difluoro-N-methylpiperidine; 4,4-Difluoro-1-methyl-piperidine; N-Methyl-4,4-difluoropiperidine; Piperidine, 4,4-difluoro-1-methyl-; 1186194-60-4; 4,4-Difluoropiperidine, 1-methyl- derivative
EINECS	Contact for details

Quality Control

Our 4,4-Difluoro-1-Methylpiperidine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and Karl Fischer titration, to ensure identity, purity, and consistency. We provide detailed Certificates of Analysis (COA) with every shipment, confirming compliance with customer specifications and relevant research-grade standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (typically 15-25°C). Keep away from heat, sparks, and open flame. For long-term storage under inert atmosphere, please contact our technical team for specific recommendations.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC/HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.