Description

Pentoxifylline-D5 is a deuterated analog of the vasodilator Pentoxifylline, specifically labeled with five deuterium atoms at key molecular positions. This stable isotope-labeled compound is essential for use as an internal standard in quantitative bioanalytical methods, ensuring the highest accuracy and reliability in pharmacokinetic and metabolic studies. It is a critical material for pharmaceutical R&D laboratories, contract research organizations (CROs), and analytical service providers engaged in advanced LC-MS/MS and GC-MS analysis.

Application

• Primary use as an internal standard in the quantitative analysis of Pentoxifylline and its metabolites using mass spectrometry techniques (LC-MS/MS, GC-MS).
• Critical component in pharmacokinetic (PK) and bioequivalence studies to ensure precise and accurate measurement of drug concentration in biological matrices.
• Facilitates drug metabolism and disposition (DMPK) research, aiding in the understanding of metabolic pathways.
• Supports clinical trial research by providing a reliable reference for monitoring drug levels in patient samples.
• Enables high-quality forensic and toxicological analysis where precise quantification is required.
• Used in the development and validation of regulatory-compliant analytical methods for Good Laboratory Practice (GLP) and clinical studies.

Basic Information

Product Name	Pentoxifylline-D5
CAS No.	1185995-18-9
Molecular Formula	C13H13D5N4O3
Molecular Weight	279.33 g/mol (approximate)
Synonyms	1-(5-Oxohexyl)-3,7-dimethyl-2,3,6,7,8-pentahydro-1H-purine-2,6-dione-d5; 3,7-Dihydro-3,7-dimethyl-1-(5-oxohexyl)-1H-purine-2,6-dione-d5; Oxpentifylline-d5; Trental-d5; BL 191-d5; [D5]-Pentoxifylline; Pentoxifylline (methyl-d3, oxo-d2)
EINECS	Contact for details

Quality Control

Our Pentoxifylline-D5 is manufactured under strict quality systems to ensure exceptional isotopic purity and chemical integrity, meeting the exacting requirements of analytical reference standards. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing parameters such as isotopic purity (Atom % D), chemical purity (by HPLC), and confirmation of structure (by NMR and MS). We support compliance with GMP/GLP guidelines for use in regulated studies.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); ensure the container is sealed tightly after each use to minimize exposure to atmospheric humidity.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity	≥ 98.0 Atom % D
Chemical Purity	≥ 95.0% (by NMR)
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.