Description

Fmoc-Aib-Cosh CAS NO 1185984-35-3 is a specialized, protected amino acid derivative used as a critical building block in solid-phase peptide synthesis (SPPS). This compound is essential for introducing the sterically hindered 2-aminoisobutyric acid (Aib) residue into peptide chains, a modification known to induce specific helical conformations and enhance metabolic stability. It is primarily utilized by research scientists and process chemists in the pharmaceutical, biotechnology, and advanced materials sectors for developing novel peptide-based therapeutics, diagnostics, and biomaterials.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key intermediate for the controlled, sequential incorporation of the non-proteinogenic amino acid Aib into custom peptide sequences.
• Pharmaceutical Research & Development: Used in the discovery and synthesis of peptide drugs, antimicrobial peptides (AMPs), and peptidomimetics where enhanced rigidity and protease resistance are desired.
• Structural Biology Studies: Employed to synthesize model peptides for studying helix formation, folding kinetics, and structure-activity relationships (SAR).
• Bioconjugation & Probe Development: Serves as a precursor for creating labeled peptides or peptide conjugates for diagnostic imaging and targeted delivery applications.
• Material Science: Facilitates the creation of synthetic peptides for bio-inspired materials, such as hydrogels and nanostructures with precise mechanical properties.

Basic Information

Product Name	Fmoc-Aib-Cosh
CAS No.	1185984-35-3
Molecular Formula	C20H19NO5S
Molecular Weight	385.43 g/mol
Synonyms	Fmoc-2-aminoisobutyric acid N-hydroxysuccinimide ester; Fmoc-Aib-OSu; Fmoc-Aib-Osu; N-(9-Fluorenylmethoxycarbonyl)-2-aminoisobutyric acid succinimidyl ester; N-α-Fmoc-2-aminoisobutyryloxysuccinimide; Fmoc-α-aminoisobutyric acid N-succinimidyl ester; Fmoc-Aib-OSU; (9H-Fluoren-9-yl)methyl (2-((2,5-dioxopyrrolidin-1-yl)oxy)-2-oxo-1,1-dimethylethyl)carbamate
EINECS	Contact for details

Quality Control

Our Fmoc-Aib-Cosh is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and NMR for structural confirmation, to ensure it meets the high standards required for sensitive synthetic applications. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting identity, purity, and impurity profiles.

Storage

Preserve in a tightly closed container, protected from light. Store in a freezer at -20°C or below. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions. Allow the sealed container to equilibrate to room temperature before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Solubility	Soluble in DMF, DMSO, acetonitrile

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.