Description

2-Cyclopropylmethoxy-5-Fluorophenylboronic Acid Pinacol Ester is a high-purity, advanced pharmaceutical intermediate and versatile building block for organic synthesis. Its core value lies in its role as a protected boronic acid derivative, offering enhanced stability and handling properties for critical cross-coupling reactions. This compound is essential for researchers and manufacturers in medicinal chemistry, particularly for the development of novel active pharmaceutical ingredients (APIs) and agrochemicals.

Application

• Suzuki-Miyaura Cross-Coupling Reactions: A key reagent for forming carbon-carbon bonds in the synthesis of complex biaryl structures.
• Pharmaceutical Intermediate: Serves as a critical building block in the research and development of new drug candidates, especially in oncology and CNS therapeutic areas.
• Agrochemical Synthesis: Used in the creation of advanced herbicides, fungicides, and insecticides with novel modes of action.
• Material Science Research: Employed in the synthesis of organic electronic materials, such as polymers and small molecules for OLEDs and OFETs.
• Chemical Biology Probes: Facilitates the synthesis of labeled compounds and probes for target identification and validation studies.
• Scale-up Process Development: Suitable for use in pilot plant and commercial-scale manufacturing under GMP conditions for API production.

Basic Information

Product Name	2-Cyclopropylmethoxy-5-Fluorophenylboronic Acid Pinacol Ester
CAS No.	1185836-97-8
Molecular Formula	C₁₆H₂₂BFO₃
Molecular Weight	292.16 g/mol
Synonyms	5-Fluoro-2-(cyclopropylmethoxy)phenylboronic acid pinacol ester; (5-Fluoro-2-(cyclopropylmethoxy)phenyl)boronic acid pinacol ester; 2-(Cyclopropylmethoxy)-5-fluorophenylboronic acid pinacol ester; Boronic acid, B-[5-fluoro-2-(cyclopropylmethoxy)phenyl]-, 1,1-dimethylethyl ester; 2-Cyclopropylmethoxy-5-fluorobenzeneboronic acid pinacol ester; CPFPE; CAS 1185836-97-8
EINECS	Contact for details

Quality Control

Every batch of 2-Cyclopropylmethoxy-5-Fluorophenylboronic Acid Pinacol Ester is manufactured under strict quality management systems. We provide comprehensive analytical data to ensure the material meets the stringent requirements for advanced synthetic applications. Our products undergo rigorous quality testing to ensure compliance with industry standards. Certificates of Analysis (COA) with detailed HPLC, NMR, and GC data are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent moisture absorption and decomposition.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Assay (HPLC)	≥97.0%
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.