Description

2-Cyclopropylmethoxy-4-Fluorophenylboronic Acid Pinacol Ester is a high-purity, advanced pharmaceutical intermediate and versatile building block for organic synthesis. Its core value lies in its role as a protected boronic acid derivative, offering enhanced stability and handling properties for critical cross-coupling reactions. This compound is essential for research chemists and process development scientists in the pharmaceutical, agrochemical, and material science industries who require reliable, high-quality reagents for constructing complex molecular architectures.

Application

• Suzuki-Miyaura Cross-Coupling Reactions: A key reagent for forming carbon-carbon bonds in the synthesis of complex biaryl structures, a common motif in active pharmaceutical ingredients (APIs).
• Pharmaceutical Intermediate: Serves as a critical building block in the research and development of novel drug candidates, particularly in oncology and central nervous system (CNS) therapeutic areas.
• Agrochemical Synthesis: Used in the development of advanced herbicides, fungicides, and insecticides that require specific fluorinated aromatic components.
• Material Science Research: Employed in the synthesis of organic electronic materials, such as polymers and small molecules for OLEDs and organic photovoltaics.
• Chemical Biology & Proteomics: Acts as a versatile handle for bioconjugation and the synthesis of molecular probes and inhibitors for target identification.
• Process Chemistry & Scale-up: Provides a stable and consistent starting material for optimizing and scaling synthetic routes from laboratory to pilot plant and commercial production.

Basic Information

Product Name	2-Cyclopropylmethoxy-4-Fluorophenylboronic Acid Pinacol Ester
CAS No.	1185836-96-7
Molecular Formula	C₁₇H₂₂BFO₃
Molecular Weight	304.17 g/mol
Synonyms	4-Fluoro-2-(cyclopropylmethoxy)phenylboronic acid pinacol ester; (4-Fluoro-2-(cyclopropylmethoxy)phenyl)boronic acid pinacol ester; 2-(Cyclopropylmethoxy)-4-fluorophenylboronic acid pinacol ester; Pinacol [2-(cyclopropylmethoxy)-4-fluorophenyl]boronate; B-[4-Fluoro-2-(cyclopropylmethoxy)phenyl]-4,4,5,5-tetramethyl-1,3,2-dioxaborolane; Boronic acid, B-[4-fluoro-2-(cyclopropylmethoxy)phenyl]-, 1,1-dimethylethyl ester; CAS 1185836-96-7
EINECS	Contact for details

Quality Control

Our 2-Cyclopropylmethoxy-4-Fluorophenylboronic Acid Pinacol Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and GC-MS, to ensure high chemical purity and identity confirmation. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all relevant specifications. Our commitment to quality supports compliance with cGMP and ICH guidelines for advanced intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Keep the container tightly sealed under an inert atmosphere to maintain stability and prevent moisture absorption.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.