Description

Ranitidine-D6 is a stable isotope-labeled analog of the histamine H2-receptor antagonist, ranitidine, where six hydrogen atoms are replaced by deuterium. This high-purity compound is essential for use as an internal standard in quantitative mass spectrometry, ensuring unparalleled accuracy and reliability in analytical measurements. It is a critical material for pharmaceutical research and development, clinical laboratories, and contract research organizations (CROs) engaged in drug metabolism, pharmacokinetic studies, and bioanalytical method development.

Application

• Internal Standard for LC-MS/MS: Primary application as a deuterated internal standard for the precise quantification of ranitidine and its metabolites in complex biological matrices like plasma, serum, and urine.
• Drug Metabolism and Pharmacokinetics (DMPK): Used in absorption, distribution, metabolism, and excretion (ADME) studies to track and measure the parent drug and its metabolic pathways.
• Bioanalytical Method Development and Validation: Critical for developing robust, sensitive, and specific analytical methods compliant with FDA, EMA, and ICH guidelines.
• Clinical and Preclinical Research: Enables accurate drug level monitoring in therapeutic drug monitoring (TDM) and toxicology studies.
• Pharmaceutical Quality Control: Supports impurity profiling and stability testing of ranitidine-based drug products.
• Forensic and Anti-Doping Analysis: Applied in specialized testing where precise identification and quantification of substances are required.

Basic Information

Item	Detail
Product Name	Ranitidine-D6
CAS No.	1185514-83-3
Molecular Formula	C13H16D6N4O3S
Molecular Weight	Approx. 314.41 g/mol
Synonyms	Deuterated Ranitidine; Ranitidine (phenyl-D5, methyl-D); N-[2-[[[5-[(Dimethylamino)(2H3)methyl]-2-furanyl](2H3)methyl]thio]ethyl]-N'-methyl-2-nitro-1,1-ethenediamine; Zantac-D6; 1,1-Ethenediamine, N-[2-[[[5-[(dimethylamino)methyl]-2-furanyl]methyl]thio]ethyl]-N'-methyl-2-nitro-, (phenyl-2H5, methyl-2H); Ranitidine-d6 (Major)
EINECS	Contact for details

Quality Control

Our Ranitidine-D6 is manufactured under strict quality systems to ensure the high chemical and isotopic purity required for sensitive analytical applications. Each batch is supported by a comprehensive Certificate of Analysis (COA) detailing parameters such as isotopic enrichment, chemical purity, and absence of interfering impurities. We adhere to industry best practices, and our quality commitment supports compliance with GLP and GMP standards for research and development use.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccant use.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (Deuterium Enrichment)	≥ 98 atom % D
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.