Description

1-Boc-5-Cyanoindole-3-Boronic Acid, Pinacol Ester is a high-purity, protected boronic acid ester building block essential for modern synthetic chemistry. This compound is a critical intermediate in the synthesis of complex molecules, particularly in pharmaceutical research and development. It is primarily utilized by medicinal chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials industries for constructing novel indole-based scaffolds via cross-coupling reactions.

Application

• Pharmaceutical Intermediate: Key building block for Suzuki-Miyaura cross-coupling reactions in the synthesis of novel drug candidates, especially kinase inhibitors and other targeted therapies.
• Medicinal Chemistry Research: Used in the exploration of structure-activity relationships (SAR) for creating diverse indole-based compound libraries.
• Agrochemical Development: Serves as a precursor in the synthesis of new active ingredients for crop protection products.
• Material Science: Potential monomer or precursor for creating functional organic materials and polymers with specific electronic properties.
• Chemical Biology: Employed in the synthesis of molecular probes and tools for studying biological pathways and protein interactions.
• Process Chemistry: Used in the scale-up and optimization of synthetic routes for active pharmaceutical ingredients (APIs).

Basic Information

Product Name	1-Boc-5-Cyanoindole-3-Boronic Acid, Pinacol Ester
CAS No.	1185427-07-9
Molecular Formula	C20H25BN2O4
Molecular Weight	368.24 g/mol
Synonyms	tert-Butyl 5-cyano-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-indole-1-carboxylate; 1-Boc-5-cyanoindole-3-boronic acid pinacol ester; 1-(tert-Butoxycarbonyl)-5-cyanoindole-3-boronic acid pinacol ester; 5-Cyano-1H-indole-1-carboxylic acid, 3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-, 1,1-dimethylethyl ester; 1-Boc-5-CN-indole-3-Bpin; BOC-5-Cyanoindole-3-Bpin
EINECS	Contact for details

Quality Control

Our 1-Boc-5-Cyanoindole-3-Boronic Acid, Pinacol Ester is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity for research and development applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to ISO 9001 quality management principles, and our analytical methods, including HPLC, NMR, and LC-MS, are validated to provide reliable data.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C (refrigerated) or as indicated on the label or COA. This material is hygroscopic (moisture-sensitive) and light-sensitive; therefore, containers must be kept sealed under an inert atmosphere (e.g., nitrogen or argon) when not in use to prevent degradation. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥97.0% (Area %)
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.