Description

Boc-α-Methyl-3-Methoxy-Dl-Phenylalanine is a protected, non-natural amino acid derivative that serves as a critical chiral building block in advanced organic synthesis. Its value lies in providing a sterically hindered, methoxy-substituted phenylalanine scaffold with orthogonal protecting groups, enabling precise control over peptide backbone modification and stereochemistry. This compound is essential for researchers and manufacturers in the pharmaceutical and biotechnology sectors, particularly for developing novel peptide-based therapeutics, protease inhibitors, and complex bioactive molecules where structural diversity and metabolic stability are paramount.

Application

• Pharmaceutical Intermediate: Key chiral synthon for the research and development of novel active pharmaceutical ingredients (APIs), especially in oncology and metabolic disease research.
• Peptidomimetic Design: Used to incorporate non-natural, sterically hindered amino acids into peptide chains to enhance metabolic stability, bioavailability, and receptor selectivity.
• Protease Inhibitor Synthesis: Serves as a core structural component in the synthesis of inhibitors targeting specific proteases like renin, HIV protease, and thrombin.
• Chemical Biology & Probe Development: Employed in creating labeled or modified peptides for studying enzyme mechanisms, protein-protein interactions, and cellular signaling pathways.
• Asymmetric Synthesis: Acts as a valuable starting material or auxiliary in catalytic asymmetric reactions to construct complex chiral molecules.
• Material Science Research: Potential building block for designing novel polymers and functional materials with specific chiral and structural properties.

Basic Information

Product Name	Boc-α-Methyl-3-Methoxy-Dl-Phenylalanine
CAS No.	1185301-00-1
Molecular Formula	C₁₆H₂₃NO₅
Molecular Weight	309.36 g/mol
Synonyms	N-(tert-Butoxycarbonyl)-α-methyl-3-methoxy-DL-phenylalanine; Boc-α-Me-3-MeO-DL-Phe-OH; tert-Butyl (1-carboxy-1-(3-methoxyphenyl)ethyl)carbamate; (±)-N-Boc-3-Methoxy-α-methylphenylalanine; DL-3-Methoxy-α-methylphenylalanine N-Boc derivative; Boc-3-Methoxy-α-methyl-DL-phenylalanine; N-Boc-α-Methyl-3-methoxyphenylalanine
EINECS	Contact for details

Quality Control

Our Boc-α-Methyl-3-Methoxy-Dl-Phenylalanine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis, and spectroscopic identification (NMR, IR, MS), to ensure it meets the high standards required for research and cGMP manufacturing. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting identity, purity, and impurity profiles.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This product is hygroscopic (moisture-sensitive) and should be handled under dry conditions to prevent decomposition. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms
Purity (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	DL-mixture (Racemic)
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.