Description

Fmoc-2-Aminothiazole-4-Acetic Acid CAS NO 1185300-16-6 is a high-purity, protected amino acid derivative essential for solid-phase peptide synthesis (SPPS). This compound serves as a critical building block for introducing the unique 2-aminothiazole-4-acetyl moiety into peptide chains, enabling the development of novel bioactive molecules. It is primarily utilized by research institutions and pharmaceutical companies engaged in drug discovery, medicinal chemistry, and the synthesis of peptide-based therapeutics and diagnostics.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key Fmoc-protected intermediate for the automated synthesis of complex peptides containing thiazole heterocycles.
• Medicinal Chemistry & Drug Discovery: Used in the research and development of new pharmaceutical candidates, particularly for creating peptide mimetics and enzyme inhibitors.
• Combinatorial Chemistry Libraries: Serves as a valuable building block for generating diverse compound libraries for high-throughput screening.
• Bioconjugation: Facilitates the site-specific modification of peptides, proteins, and other biomolecules for diagnostic or therapeutic purposes.
• Chemical Biology Research: Employed in studying protein-protein interactions and developing chemical probes.
• API Intermediate: Acts as a sophisticated intermediate in the multi-step synthesis of Active Pharmaceutical Ingredients (APIs).

Basic Information

Product Name	Fmoc-2-Aminothiazole-4-Acetic Acid
CAS No.	1185300-16-6
Molecular Formula	C₂₁H₁₈N₂O₅S
Molecular Weight	410.44 g/mol
Synonyms	Fmoc-ATA-OH; 2-[[(9H-Fluoren-9-ylmethoxy)carbonyl]amino]-1,3-thiazole-4-acetic acid; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-2-aminothiazole-4-acetic acid; N-Fmoc-2-aminothiazole-4-acetic acid; Fmoc-2-amino-1,3-thiazole-4-acetic acid; 4-Carboxymethyl-2-aminothiazole N-Fmoc derivative; (2-Amino-1,3-thiazol-4-yl)acetic acid N-Fmoc derivative
EINECS	Contact for details

Quality Control

Our Fmoc-2-Aminothiazole-4-Acetic Acid is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity suitable for research and pharmaceutical applications. We provide comprehensive Certificates of Analysis (COA) with each batch, detailing purity, identity, and impurity profiles. Our quality systems are designed to meet the stringent requirements of cGMP and ICH guidelines for advanced pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This product is hygroscopic (moisture-sensitive) and should be handled under dry, inert conditions to maintain stability and purity. Allow the container to reach room temperature before opening to prevent moisture condensation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm
Residual Solvents (GC)	Complies with ICH Q3C

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.