Description

2-Desethoxy-2-Hydroxy-2H-2-Ethyl Candesartan Cilexetil is a key pharmaceutical intermediate in the synthesis of the active pharmaceutical ingredient (API) Candesartan Cilexetil, an angiotensin II receptor blocker (ARB) used to treat hypertension. This compound is critical for ensuring the purity, efficacy, and regulatory compliance of the final drug product. It is primarily utilized by pharmaceutical manufacturers, research institutions, and contract development and manufacturing organizations (CDMOs) engaged in the production of cardiovascular medications and advanced pharmaceutical research.

Application

• Primary Intermediate in the commercial synthesis of Candesartan Cilexetil API.
• Process Development & Optimization for scaling up ARB drug manufacturing.
• Reference Standard for analytical method development and validation in quality control laboratories.
• Impurity Profiling and characterization studies to meet ICH guidelines for drug substance specifications.
• Research Chemical for investigating new synthetic pathways or derivative compounds in medicinal chemistry.
• GMP Manufacturing of finished dosage forms under strict regulatory frameworks (e.g., US FDA, EMA).

Basic Information

Product Name	2-Desethoxy-2-Hydroxy-2H-2-Ethyl Candesartan Cilexetil
CAS No.	1185256-03-4
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	Candesartan Cilexetil Impurity; Candesartan Cilexetil Intermediate; 2-Desethoxy-2-hydroxy Candesartan Cilexetil; 2-Hydroxy-2H-2-ethyl Candesartan Cilexetil; (2-((2'-(2H-Tetrazol-5-yl)-[1,1'-biphenyl]-4-yl)methyl)-4-oxo-3-((2-(2-ethoxy-2-oxoethoxy)ethyl)carbamoyl)-4H-chromen-7-yl)oxy)acetic acid; Candesartan Cilexetil Related Compound; ARB Intermediate; BPHA Impurity
EINECS	Contact for details

Quality Control

Our products undergo rigorous quality testing to ensure compliance with industry standards for pharmaceutical intermediates. Quality is assured through analytical techniques including HPLC, NMR, and MS. Certificates of Analysis (COA) are available upon request, detailing purity, identity, and impurity profiles. We support compliance with ICH Q3A/B, USP, and EP guidelines, and can supply material suitable for GMP manufacturing processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%
Residual Solvents (GC)	Meets ICH Q3C limits
Loss on Drying	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.