Description

2-Desethoxy-2-Hydroxy-1H-1-Ethyl Candesartan Cilexetil is a key pharmaceutical intermediate in the synthesis of active pharmaceutical ingredients (APIs). This compound is of critical importance for ensuring the purity, efficacy, and regulatory compliance of final drug products. It is primarily required by manufacturers in the pharmaceutical and fine chemical industries engaged in the development and production of cardiovascular medications.

Application

• Pharmaceutical Intermediate: A crucial building block in the synthesis of Candesartan Cilexetil and related angiotensin II receptor antagonists (ARBs).
• Active Pharmaceutical Ingredient (API) Development: Used in research and process development for new cardiovascular drug formulations.
• Process Chemistry & Scale-Up: Serves as a reference standard and a starting material for optimizing manufacturing routes in pilot plants and commercial production.
• Quality Control & Analytical Testing: Employed as a certified reference material (CRM) or impurity standard in HPLC and other analytical methods to ensure batch-to-batch consistency.
• Regulatory Filings: Essential for compiling Chemistry, Manufacturing, and Controls (CMC) documentation for regulatory submissions to agencies like the FDA and EMA.

Basic Information

Item	Detail
Product Name	2-Desethoxy-2-Hydroxy-1H-1-Ethyl Candesartan Cilexetil
CAS No.	1185255-99-5
Molecular Formula	C33H34N6O6
Molecular Weight	610.67 g/mol
Synonyms	2-Desethoxy-2-hydroxy-1H-1-ethyl candesartan cilexetil; 1H-1-Ethyl-2-desethoxy-2-hydroxy candesartan cilexetil; Candesartan Cilexetil Impurity; Candesartan Cilexetil Intermediate; Candesartan Related Compound; UNII-9K5L8V6Y8T; 2-Desethoxy-2-hydroxy candesartan ethyl ester derivative
EINECS	Contact for details

Quality Control

Our 2-Desethoxy-2-Hydroxy-1H-1-Ethyl Candesartan Cilexetil is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the high standards required for pharmaceutical intermediates. Certificates of Analysis (COA) with detailed chromatographic data are available upon request to support your quality and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept in a dry environment to prevent degradation. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.