Description

(5Z)-5-[[4-[1,1,2,2-Tetradeuterio-2-[5-(2-Methyl-1,3-Dioxolan-2-Yl)Pyridin-2-Yl]Ethoxy]Phenyl]Methylidene]-1,3-Thiazolidine-2,4-Dione is a deuterated analog of a thiazolidinedione derivative, a class of compounds with significant research interest. This compound is primarily valued as a stable isotope-labeled internal standard for precise analytical quantification in complex biological matrices. It is an essential tool for researchers and quality control laboratories in the pharmaceutical and life sciences sectors, particularly those focused on metabolic disease research and drug development.

Application

• Internal Standard for LC-MS/MS Analysis: Used for the accurate quantification of its non-deuterated counterpart in pharmacokinetic (PK), pharmacodynamic (PD), and bioanalytical studies.
• Drug Metabolism and Pharmacokinetics (DMPK) Research: Enables precise tracking of drug candidate absorption, distribution, metabolism, and excretion (ADME) profiles.
• Pharmaceutical Impurity Profiling: Serves as a critical reference standard in the development and validation of analytical methods to ensure drug purity and safety.
• Biomarker Discovery and Validation: Facilitates the accurate measurement of endogenous or drug-related metabolites in clinical and preclinical research.
• Stable Isotope Labeling Studies: Employed in mechanistic studies to elucidate metabolic pathways and degradation products.

Basic Information

Item	Details
Product Name	(5Z)-5-[[4-[1,1,2,2-Tetradeuterio-2-[5-(2-Methyl-1,3-Dioxolan-2-Yl)Pyridin-2-Yl]Ethoxy]Phenyl]Methylidene]-1,3-Thiazolidine-2,4-Dione
CAS No.	1185247-50-0
Molecular Formula	C21H19D4NO4S
Molecular Weight	397.50 g/mol
Synonyms	Deuterated Thiazolidinedione Derivative; 2,4-Thiazolidinedione, 5-[[4-[1,1,2,2-tetradeuterio-2-[5-(2-methyl-1,3-dioxolan-2-yl)-2-pyridinyl]ethoxy]phenyl]methylene]-, (5Z)-; (5Z)-5-((4-((2-(5-(2-Methyl-1,3-dioxolan-2-yl)pyridin-2-yl)-1,1,2,2-d4)ethoxy)benzylidene)thiazolidine-2,4-dione; Deuterium-labeled TZD analog; [D4]-Labeled Internal Standard; 1185247-50-0; 5-[[4-[1,1,2,2-Tetradeuterio-2-[5-(2-Methyl-1,3-Dioxolan-2-Yl)Pyridin-2-Yl]Ethoxy]Phenyl]Methylidene]-1,3-Thiazolidine-2,4-Dione
EINECS	Contact for details

Quality Control

Our deuterated standards are produced under strict quality control protocols to ensure the highest isotopic purity and chemical integrity, which is critical for accurate mass spectrometry. Each batch is analyzed by advanced techniques including NMR (¹H, ¹³C) for structural confirmation and HPLC-MS for chemical and isotopic purity assessment. A comprehensive Certificate of Analysis (COA) detailing batch-specific data, including isotopic enrichment (D%), is provided with every shipment to support your regulatory and research documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a freezer. This compound is hygroscopic (moisture-sensitive). Allow the sealed vial to equilibrate to room temperature before opening to minimize moisture condensation. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (D%)	≥ 98.0 atom % D
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.