Description

Trimipramine-D3 Maleate is a high-purity, deuterium-labeled internal standard critical for modern analytical chemistry. This stable isotope-labeled compound is essential for ensuring the accuracy, precision, and reliability of quantitative mass spectrometry analyses. It is primarily used by pharmaceutical R&D laboratories, contract research organizations (CROs), and forensic toxicology labs for method development, validation, and routine testing.

Application

• Quantitative Bioanalysis: Serves as an internal standard for the precise quantification of Trimipramine and its metabolites in biological matrices (plasma, serum, urine) using LC-MS/MS.
• Pharmacokinetic/Pharmacodynamic (PK/PD) Studies: Enables accurate tracking of drug absorption, distribution, metabolism, and excretion in clinical and preclinical research.
• Therapeutic Drug Monitoring (TDM): Supports the reliable measurement of Trimipramine levels in patient samples to optimize dosage and ensure therapeutic efficacy.
• Forensic and Clinical Toxicology: Used in confirmatory testing for the presence of tricyclic antidepressants in forensic investigations or overdose cases.
• Drug Metabolism and Disposition Studies: Facilitates the identification and quantification of drug metabolites in complex in vitro and in vivo systems.
• Method Development and Validation: A key reagent for developing robust, sensitive, and selective analytical methods compliant with FDA, EMA, and ICH guidelines.
• Quality Control in Pharmaceutical Manufacturing: Can be employed in impurity profiling and stability-indicating assays for drug substance and product.

Basic Information

Product Name	Trimipramine-D3 Maleate
CAS No.	1185245-93-5
Molecular Formula	C23H26D3N2O4
Molecular Weight	406.52 g/mol
Synonyms	5-[3-(Dimethylamino)-2-methylpropyl]-10,11-dihydro-5H-dibenzo[b,f]azepine-d3 maleate; Trimipramine-d3 maleate salt; Deuterated Trimipramine Maleate; Trimipramine (methyl-d3) maleate; 2-Methyl-11-(4-methyl-1-piperazinyl)dibenz[b,f][1,4]oxazepine-d3 maleate; Surmontil-d3 maleate
EINECS	Contact for details

Quality Control

Every batch of Trimipramine-D3 Maleate is manufactured and tested under strict quality management systems. We guarantee high chemical and isotopic purity, supported by comprehensive analytical data including NMR, HPLC, and mass spectrometry. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting purity, isotopic enrichment, and other critical parameters to ensure compliance with your research and regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as indicated on the label. This product is hygroscopic (moisture-sensitive) and should be kept in a dry environment. For long-term storage, consider desiccation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity	≥ 99.0 atom % D
Chemical Purity	≥ 95.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.