Description

n-Desmethylcarboxy Terbinafine-D7, Methyl Ester is a high-purity, deuterium-labeled internal standard critical for precise analytical quantification. This compound is essential for ensuring accuracy and reliability in bioanalytical studies, particularly in pharmacokinetic and metabolism research. It is primarily required by pharmaceutical R&D laboratories, contract research organizations (CROs), and analytical testing facilities specializing in method development and validation for antifungal agents.

Application

• Internal Standard for LC-MS/MS: Used as a deuterated internal standard for the accurate quantification of terbinafine and its metabolites in complex biological matrices like plasma, serum, and tissue homogenates.
• Pharmaceutical R&D: Supports method development and validation in drug metabolism and pharmacokinetics (DMPK) studies for antifungal drug candidates.
• Clinical Research: Enables precise therapeutic drug monitoring (TDM) and bioequivalence studies for formulations containing terbinafine.
• Forensic & Toxicology Analysis: Facilitates the detection and quantification of terbinafine in forensic and toxicological screenings with high specificity.
• Quality Control in Manufacturing: Serves as a reference standard in the quality control of active pharmaceutical ingredients (APIs) and finished drug products.
• Metabolite Identification: Aids in the structural elucidation and tracking of metabolite pathways in in vitro and in vivo studies.

Basic Information

Item	Details
Product Name	n-Desmethylcarboxy Terbinafine-D7, Methyl Ester
CAS No.	1185245-14-0
Molecular Formula	C22H28D7NO
Molecular Weight	327.55 g/mol (approx.)
Synonyms	Terbinafine D7 Metabolite Methyl Ester; (E)-N-(6,6-Dimethyl-2-hepten-4-ynyl)-N-methyl-1-naphthalenemethanamine-d7 Methyl Ester; Terbinafine Carboxylic Acid Metabolite D7 Methyl Ester; n-Desmethylcarboxy Terbinafine D7 Methyl Ester; Terbinafine-d7 Methyl Ester Derivative; Deuterated Terbinafine Internal Standard; [D7]-Terbinafine Methyl Ester Metabolite; ATCC 1185245-14-0
EINECS	Contact for details

Quality Control

Our n-Desmethylcarboxy Terbinafine-D7, Methyl Ester is manufactured under strict quality systems to ensure exceptional purity and isotopic enrichment suitable for sensitive analytical applications. Each batch is supported by comprehensive analytical data, including HPLC, NMR, and mass spectrometry to confirm chemical and isotopic purity. Certificates of Analysis (COA) detailing batch-specific results are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as indicated on the label. This material is hygroscopic (moisture-sensitive) and must be kept in a dry environment. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (D-content)	≥ 98.0 atom % D
Chemical Purity (NMR)	Conforms
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.