Description

Cinnarizine-D8 is a deuterated analog of the pharmaceutical compound Cinnarizine, specifically labeled with eight deuterium atoms. This stable isotope-labeled standard is essential for ensuring accuracy and reliability in quantitative analytical methods, particularly in pharmacokinetic and metabolic studies. It is a critical material for research laboratories, pharmaceutical developers, and contract research organizations (CROs) engaged in advanced drug development and bioanalytical method validation.

Application

• As an internal standard for the precise quantification of Cinnarizine in biological matrices using LC-MS/MS and GC-MS.
• In pharmacokinetic studies to investigate the absorption, distribution, metabolism, and excretion (ADME) profile of Cinnarizine.
• For method development and validation in bioanalytical laboratories to meet regulatory requirements (e.g., FDA, EMA).
• In drug metabolism research to identify and characterize metabolites without interference from the endogenous compound.
• Use in quality control processes within pharmaceutical manufacturing for assay standardization.
• As a critical reagent in clinical research and therapeutic drug monitoring (TDM) protocols.

Basic Information

Product Name	Cinnarizine-D8
CAS No.	1185242-27-6
Molecular Formula	C26H20D8N2
Molecular Weight	~ 376.56 g/mol
Synonyms	1-(Diphenylmethyl)-4-[(E)-3-phenyl-2-propen-1-yl]-piperazine-d8; Cinnarizine (phenyl-d5, allyl-d3); Cinnarizine-d8; Deuterated Cinnarizine; Cinnarizine Internal Standard; [2H8]-Cinnarizine; (E)-1-(Diphenylmethyl)-4-(3-phenylallyl)piperazine-d8; 1-Benzhydryl-4-cinnamylpiperazine-d8
EINECS	Contact for details

Quality Control

Our Cinnarizine-D8 is produced under strict quality management systems. Each batch undergoes rigorous analytical testing, including NMR and mass spectrometry, to confirm isotopic purity and chemical identity. We provide comprehensive Certificates of Analysis (COA) detailing chemical purity, isotopic enrichment (D%), and chromatographic purity to support your regulatory submissions and ensure data integrity.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); ensure the container is sealed after each use to minimize exposure to atmospheric moisture. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (MS)	Conforms
Purity (HPLC)	≥ 98.0%
Isotopic Purity (D%)	≥ 98 atom % D
Chemical Purity (NMR)	Conforms
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.