Description

Ethyl 3-(4-Fluorophenyl)-2-(2-Methylpropionyl)Propenoate-D6 is a high-purity, deuterium-labeled analog of a key pharmaceutical intermediate, offering a critical tool for advanced research and development. This stable isotope-labeled compound is essential for conducting precise pharmacokinetic, metabolic, and bioanalytical studies, providing superior data accuracy and reliability. It is primarily utilized by pharmaceutical companies, contract research organizations (CROs), and academic institutions engaged in the development and analysis of active pharmaceutical ingredients (APIs) and novel drug candidates.

Application

• Internal Standard for LC-MS/MS: Serves as a critical quantitative internal standard in liquid chromatography-tandem mass spectrometry (LC-MS/MS) for bioanalytical method development and validation.
• Drug Metabolism and Pharmacokinetics (DMPK): Used in absorption, distribution, metabolism, and excretion (ADME) studies to track and quantify the parent drug and its metabolites in biological matrices.
• Pharmaceutical Impurity Profiling: Aids in the identification and quantification of process-related impurities and degradation products during API synthesis and quality control.
• Metabolite Identification: Facilitates the structural elucidation of drug metabolites by providing a mass spectrometric reference point with a distinct isotopic pattern.
• Clinical Research: Enables accurate therapeutic drug monitoring and pharmacokinetic profiling in clinical trial samples.
• Isotope Dilution Analysis: Employed in high-precision analytical techniques to improve accuracy and correct for sample preparation losses.

Basic Information

Product Name	Ethyl 3-(4-Fluorophenyl)-2-(2-Methylpropionyl)Propenoate-D6
CAS No.	1185241-64-8
Molecular Formula	C15H13D6FO3
Molecular Weight	Contact for details
Synonyms	Ethyl (E)-3-(4-Fluorophenyl)-2-(2-methylpropanoyl)prop-2-enoate-d6; Ethyl 3-(4-Fluorophenyl)-2-isobutyrylacrylate-d6; (E)-Ethyl 3-(4-fluorophenyl)-2-(2-methylpropanoyl)acrylate-d6; Deuterated Ethyl 3-(4-Fluorophenyl)-2-(2-methylpropionyl)propenoate; [2H6]-Ethyl 3-(4-Fluorophenyl)-2-(2-methylpropionyl)propenoate; Ethyl 3-(p-Fluorophenyl)-2-isobutyrylacrylate-d6; Stable Isotope Labeled Pharmaceutical Intermediate
EINECS	Contact for details

Quality Control

Our deuterated compounds are manufactured under strict quality control protocols to ensure exceptional isotopic purity and chemical integrity, essential for sensitive analytical applications. Each batch is supported by a comprehensive Certificate of Analysis (COA) detailing parameters such as chemical purity, isotopic enrichment, and solvent content. We adhere to cGMP principles where applicable to support our clients' regulatory submissions. Certificates of Analysis (COA) are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a dry, well-ventilated area. Keep away from strong acids and incompatible organic solvents. For long-term storage, consider storing under an inert atmosphere to maintain optimal stability and isotopic integrity.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (NMR/MS)	≥ 98.0 atom % D
Chemical Purity (by HPLC)	≥ 95.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.