Description

4-Keto 9-Cis Retinoic Acid-D3 is a deuterated isotopologue of a key retinoid derivative, offering enhanced metabolic stability for advanced research and development. This compound is critical for studies in cell differentiation, proliferation, and signaling pathways, particularly where precise tracking of the parent molecule is required. It serves as an indispensable reference standard and synthetic intermediate for pharmaceutical, biotechnology, and academic research institutions focused on dermatology, oncology, and metabolic diseases.

Application

• Pharmaceutical Reference Standard: Used for the quantitative analysis and method validation in the development of retinoid-based therapies.
• Metabolic Pathway Tracing: Acts as a stable isotope-labeled internal standard in LC-MS and GC-MS assays to study the pharmacokinetics and biotransformation of retinoids.
• Biochemical Research: Employed in mechanistic studies of nuclear receptor signaling, particularly related to RAR and RXR receptors.
• Synthetic Intermediate: Serves as a key building block for the synthesis of novel, labeled retinoid analogs for drug discovery programs.
• Cosmeceutical R&D: Utilized in advanced research for developing next-generation anti-aging and skin-rejuvenation formulations.

Basic Information

Product Name	4-Keto 9-Cis Retinoic Acid-D3
CAS No.	1185241-31-9
Molecular Formula	C20H25D3O3
Molecular Weight	319.45 g/mol
Synonyms	9-cis-4-Oxoretinoic Acid-d3; 9-Cis-4-Ketoretinoic Acid-d3; 4-Keto-9-cis-Retinoic Acid-d3; (2E,4E,6Z,8E)-3,7-Dimethyl-9-(2,6,6-trimethyl-1-cyclohexen-1-yl)-2,4,6,8-nonatetraenoic-19,19,19-d3 Acid-4-one; Labeled 4-Keto-9cRA; Deuterated 4-Keto-9cRA; 4-Oxo-9-cis-RA-d3
EINECS	Contact for details

Quality Control

Our 4-Keto 9-Cis Retinoic Acid-D3 is manufactured under strict quality systems. Each batch is characterized and tested to ensure high chemical and isotopic purity, meeting the stringent requirements for research and development. Comprehensive analytical data, including HPLC purity, NMR confirmation, and MS isotopic enrichment, are documented in the batch-specific Certificate of Analysis (COA), available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere (e.g., argon or nitrogen) to prevent oxidation. Allow the container to reach room temperature in a desiccator before opening to minimize moisture absorption.

Specification

Item	Specification
Appearance	Yellow to orange crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Enrichment (MS)	≥ 98 atom % D
Chemical Purity	≥ 95%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.