Description

Entacapone-D10 is a deuterium-labeled internal standard of the pharmaceutical compound Entacapone, specifically designed for use in quantitative analytical methods. This high-purity, isotopically labeled standard is essential for ensuring the accuracy and reliability of mass spectrometry-based analyses, such as LC-MS/MS, in pharmacokinetic and bioequivalence studies. It is a critical tool for pharmaceutical research and development laboratories, contract research organizations (CROs), and quality control units requiring precise measurement of Entacapone in complex biological matrices.

Application

• Primary use as an internal standard for the quantification of Entacapone via LC-MS/MS and GC-MS.
• Method development and validation in bioanalytical studies for drug metabolism and pharmacokinetics (DMPK).
• High-accuracy analysis in clinical trial sample testing and bioequivalence assessments.
• Quality control and impurity profiling in active pharmaceutical ingredient (API) manufacturing.
• Supporting research into the pharmacodynamics of catechol-O-methyltransferase (COMT) inhibitors.
• Use in forensic and toxicological analysis for precise drug level determination.

Basic Information

Product Name	Entacapone-D10
CAS No.	1185241-19-3
Molecular Formula	C14H5D10N2O5
Molecular Weight	305.33 g/mol (for D10 isotopologue)
Synonyms	(E)-2-Cyano-3-(3,4-dihydroxy-5-nitrophenyl)-N,N-diethyl-2-propenamide-D10; Entacapone-d10; Deuterated Entacapone; Entacapone (phenyl-D5, diethyl-D5); COMT Inhibitor-D10; OR-611-D10; Comtan-D10 (labeled standard)
EINECS	Contact for details

Quality Control

Every batch of Entacapone-D10 is manufactured and analyzed under strict quality systems to ensure it meets the exacting standards required for analytical reference materials. Our quality commitment includes comprehensive characterization by NMR, MS, and HPLC to confirm isotopic purity (≥98% D) and chemical purity (≥98%). A detailed Certificate of Analysis (COA) is provided with each shipment, documenting batch-specific results for identity, assay, and purity. We support compliance needs for research under GLP and cGMP frameworks.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as indicated on the label or COA. This material is hygroscopic (moisture-sensitive) and must be kept in a dry environment. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	Yellow to brownish-yellow solid
Identification (HPLC)	Conforms
Identification (MS)	Conforms
Purity (HPLC)	≥ 98.0%
Isotopic Purity (D-content)	≥ 98 atom % D
Chemical Purity	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.