Description

13-cis-Acitretin-D3 is a deuterated isotopologue of the synthetic retinoid acitretin, specifically labeled on the 13-cis isomer. This compound serves as a critical internal standard in bioanalytical research, enabling precise quantification and pharmacokinetic studies of its non-deuterated counterpart. It is primarily utilized by pharmaceutical R&D laboratories, contract research organizations (CROs), and academic institutions focused on dermatology and oncology. The deuterium labeling provides enhanced stability for mass spectrometry analysis, ensuring reliable and accurate data.

Application

• Bioanalytical Internal Standard: Essential for Liquid Chromatography-Mass Spectrometry (LC-MS/MS) method development and validation for acitretin quantification in biological matrices.
• Pharmacokinetic and Metabolism Studies: Used in ADME (Absorption, Distribution, Metabolism, Excretion) research to track drug levels and metabolic pathways.
• Pharmaceutical Quality Control: Supports assay development and impurity profiling for acitretin-based drug products.
• Clinical Research: Facilitates therapeutic drug monitoring and bioavailability studies in clinical trials for psoriasis and other retinoid therapies.
• Reference Material: Acts as a certified reference standard for calibrating analytical instruments and ensuring regulatory compliance.

Basic Information

Product Name	13-cis-Acitretin-D3
CAS No.	1185241-03-5
Molecular Formula	C21H25D3O3
Molecular Weight	327.46 g/mol (approx.)
Synonyms	(2Z,4E,6E,8E)-9-(4-Methoxy-2,3,6-trimethylphenyl)-3,7-dimethyl-9-(2,6,6-trimethyl-1-cyclohexen-1-yl)-2,4,6,8-nonatetraenoic Acid-d3; 13-cis-Acitretin-d3; Isotretinoin-d3 (related analog); Etretin D3; Neotigason-d3 (related analog); Ro 10-1670-d3; All-trans-3,7-dimethyl-9-(2,6,6-trimethyl-1-cyclohexen-1-yl)-2,4,6,8-nonatetraenoic Acid-d3 (isomeric form).
EINECS	Contact for details

Quality Control

Our 13-cis-Acitretin-D3 is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for chemical purity and isotopic enrichment, NMR for structural confirmation, and mass spectrometry for identity. We provide a detailed Certificate of Analysis (COA) with each shipment, which includes batch-specific data on purity, isotopic purity (D-enrichment), and residual solvents. Our quality commitment ensures the material meets the high standards required for regulatory submission and sensitive analytical applications.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere for long-term stability. This product is hygroscopic (moisture-sensitive); allow the sealed vial to equilibrate to room temperature before opening to prevent condensation. For short-term use, store desiccated at 2-8°C.

Specification

Item	Specification
Appearance	Yellow to orange crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (D-enrichment)	≥ 98 atom % D
Chemical Purity (by NMR)	Conforms
Residual Solvents (GC)	Meets ICH guidelines
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.