Description

Methyl 4'-Tosyl Mycophenoate-6-Methyl-D3 is a high-purity, deuterium-labeled derivative of mycophenolic acid, a critical intermediate in pharmaceutical research and development. This compound is specifically designed for use as an internal standard in quantitative bioanalytical methods, ensuring unparalleled accuracy and reliability in pharmacokinetic and metabolic studies. It is an essential tool for researchers and quality control laboratories in the pharmaceutical and biotechnology sectors who require precise measurement of mycophenolic acid and its metabolites.

Application

• Bioanalytical Internal Standard: Primary use as a deuterated internal standard in Liquid Chromatography-Mass Spectrometry (LC-MS) and LC-MS/MS for the quantification of mycophenolic acid in biological matrices.
• Pharmacokinetic Research: Enables accurate tracking of drug absorption, distribution, metabolism, and excretion (ADME) for mycophenolate mofetil and related prodrugs.
• Metabolite Studies: Facilitates the identification and quantification of mycophenolic acid metabolites in preclinical and clinical research.
• Method Development & Validation: Critical for developing and validating robust, regulatory-compliant analytical methods in Good Laboratory Practice (GLP) and Good Clinical Practice (GCP) environments.
• Therapeutic Drug Monitoring (TDM): Supports accurate TDM assays for patients undergoing immunosuppressive therapy, aiding in dose optimization.
• Stable Isotope Labeling: Serves as a key reagent in the synthesis of other labeled compounds for advanced mass spectrometry applications.

Basic Information

Item	Detail
Product Name	Methyl 4'-Tosyl Mycophenoate-6-Methyl-D3
CAS No.	1185240-84-9
Molecular Formula	C27H25D3O7S
Molecular Weight	507.57 g/mol
Synonyms	Mycophenolic Acid 6-Methyl-d3 Methyl Ester 4'-Tosylate; Mycophenolate 6-Methyl-d3 Tosylate; 4-Methyl-6-[(E)-4-tosyloxy-6-methoxy-7-methyl-3-oxo-1,3-dihydro-2-benzofuran-5-yl]-4-hexenoic Acid Methyl Ester-6-methyl-d3; (E)-6-(1,3-Dihydro-4-hydroxy-6-methoxy-7-methyl-3-oxo-5-isobenzofuranyl)-4-methyl-4-hexenoic Acid Methyl Ester 4'-Tosylate-6-methyl-d3; Deuterated Mycophenolic Acid Tosylate Ester; MPA-d3 Tosylate Methyl Ester.
EINECS	Contact for details

Quality Control

Every batch of Methyl 4'-Tosyl Mycophenoate-6-Methyl-D3 is manufactured and analyzed under strict quality systems to ensure it meets the exacting standards required for analytical reference materials. Our products undergo rigorous quality testing, including identity confirmation, purity assessment, and isotopic enrichment verification, to ensure compliance with industry standards. A comprehensive Certificate of Analysis (COA) detailing batch-specific results for purity, isotopic purity, and related substances is provided with each shipment and is available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a dry environment. This material is light-sensitive (store away from light).

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Isotopic Purity (MS)	≥ 99.0 atom % D (at labeled position)
Chemical Purity	≥ 95.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.