Description

Dl-Benflumelol-D18 is a deuterated analog of benflumetol, a key intermediate in the synthesis of antimalarial compounds. This stable isotope-labeled compound is essential for use as an internal standard in quantitative mass spectrometry, ensuring unparalleled accuracy and reliability in analytical research. It is primarily required by pharmaceutical R&D laboratories, contract research organizations (CROs), and manufacturers of reference standards for drug metabolism, pharmacokinetic (DMPK) studies, and bioanalytical method development.

Application

• Internal standard for the quantitative LC-MS/MS analysis of benflumetol and its metabolites in biological matrices.
• Critical component in bioanalytical method development and validation for antimalarial drug studies.
• Use in drug metabolism and pharmacokinetic (DMPK) research to track drug distribution and clearance.
• Reference material for ensuring regulatory compliance and data integrity in pharmaceutical quality control.
• Essential reagent in clinical research for accurate therapeutic drug monitoring (TDM).
• Tool for forensic and anti-doping analysis where precise quantification of specific compounds is required.

Basic Information

Product Name	Dl-Benflumelol-D18
CAS No.	1185240-53-2
Molecular Formula	C30H24D18Cl3N2O
Molecular Weight	528.98 g/mol (deuterated form)
Synonyms	Benflumetol-d18; Lumefantrine-d18; (±)-Benflumetol-d18; 2-Dichloro-α-[(dibutylamino)methyl]-9-fluoro-7-(4-trideuteromethoxyphenyl)-4H-fluorene-4-methanol-d15; 1-[(9Z)-2,7-Dichloro-9-[(4-chlorophenyl)methylene]-9H-fluoren-4-yl]-N,N-dibutylmethanamine-d18; CGP 56697-d18; C30H24D18Cl3N2O
EINECS	Contact for details

Quality Control

Our Dl-Benflumelol-D18 is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including NMR, HPLC, and mass spectrometry, to confirm chemical identity, isotopic purity (D-enrichment), and chemical purity. Certificates of Analysis (COA) detailing all specifications and test results are provided with every shipment to ensure traceability and support your regulatory submissions.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption, which can affect stability and analytical performance.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (NMR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (D-enrichment)	≥ 98 atom % D
Chemical Purity	≥ 95%
Residual Solvents (GC)	Complies with ICH guidelines
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.