Description

n-Desmethylcarboxy Terbinafine-D7 is a high-purity, deuterium-labeled internal standard critical for precise analytical quantification. This compound is essential for ensuring accuracy and reliability in sophisticated mass spectrometry-based analyses, particularly in pharmacokinetic and metabolic studies. It is primarily required by pharmaceutical R&D laboratories, contract research organizations (CROs), and analytical service providers specializing in bioanalytical method development and validation.

Application

• Internal Standard for LC-MS/MS: Used as a deuterated internal standard for the accurate quantification of terbinafine and its metabolites in complex biological matrices like plasma, serum, and tissue homogenates.
• Drug Metabolism and Pharmacokinetics (DMPK): Facilitates reliable studies on the absorption, distribution, metabolism, and excretion (ADME) profile of antifungal agents.
• Bioanalytical Method Development: Serves as a critical reference compound for developing and validating robust, sensitive, and specific HPLC or UPLC-MS/MS methods.
• Clinical Research & Therapeutic Drug Monitoring (TDM): Enables precise measurement of drug concentrations in patient samples to optimize dosing regimens and ensure therapeutic efficacy.
• Forensic and Anti-Doping Analysis: Supports high-confidence identification and quantification of terbinafine in forensic toxicology and sports doping control applications.
• Pharmaceutical Quality Control: Employed in impurity profiling and stability studies of drug substances and products containing terbinafine.

Basic Information

Product Name	n-Desmethylcarboxy Terbinafine-D7
CAS No.	1185238-58-7
Molecular Formula	C21H18D7ClN
Molecular Weight	327.93 g/mol (for D7 isotopologue)
Synonyms	Terbinafine Carboxylic Acid-D7; Terbinafine-D7 Carboxylic Acid; (E)-N-(6,6-Dimethyl-2-hepten-4-ynyl)-N-methyl-1-naphthalenemethanamine-3,3,4,4,5,5,5-d7 Carboxylic Acid; N-Desmethyl Terbinafine Carboxylic Acid-D7; Terbinafine Metabolite M1-D7; Terbinafine Acid-D7; Deuterated Terbinafine Carboxylic Acid; [D7]-Terbinafine Carboxylic Acid
EINECS	Contact for details

Quality Control

Every batch of n-Desmethylcarboxy Terbinafine-D7 is manufactured and analyzed under strict quality systems. We guarantee high chemical and isotopic purity, supported by comprehensive analytical data including NMR, HPLC, and mass spectrometry. Certificates of Analysis (COA) detailing batch-specific purity, isotopic enrichment, and chromatographic data are provided and available upon request to support your regulatory and research documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as indicated on the label or COA. For long-term storage, keep the container in a cool, dry, and well-ventilated area.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (MS)	≥ 98.0 atom % D
Chemical Purity (NMR)	Conforms
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.