Description

Ranitidine D6 HCl is a deuterium-labeled internal standard of the histamine H2-receptor antagonist, ranitidine hydrochloride. This high-purity, isotopically enriched compound is essential for ensuring accuracy and reliability in quantitative mass spectrometry-based analyses. It is primarily required by analytical laboratories and pharmaceutical R&D departments engaged in pharmacokinetic studies, drug metabolism research, and bioanalytical method development and validation.

Application

• Internal Standard for LC-MS/MS and GC-MS quantification of ranitidine in biological matrices (plasma, serum, urine).
• Use in pharmacokinetic and bioequivalence studies to track drug absorption, distribution, metabolism, and excretion.
• Critical component in stable isotope dilution assays for high-precision analytical measurements.
• Method development and validation in pharmaceutical quality control and forensic toxicology laboratories.
• Research into drug-drug interactions and metabolic pathways of H2-receptor antagonists.
• Calibration and quality assurance for regulatory submissions to agencies like the FDA and EMA.

Basic Information

Item	Detail
Product Name	Ranitidine D6 HCl
CAS No.	1185238-09-8
Molecular Formula	C13H16D6ClN4O3S
Molecular Weight	350.86 g/mol (for D6 labeled form)
Synonyms	Ranitidine-d6 Hydrochloride; [2H6]-Ranitidine HCl; N-[2-[[[5-[(Dimethylamino-d6)methyl]-2-furanyl]methyl]thio]ethyl]-N'-methyl-2-nitro-1,1-ethenediamine Hydrochloride; Zantac-d6 HCl; Deuterated Ranitidine HCl; Ranitidine (methyl-d6) Hydrochloride; Internal Standard for Ranitidine
EINECS	Contact for details

Quality Control

Our Ranitidine D6 HCl is manufactured under controlled conditions to meet the exacting standards required for analytical reference materials. Each batch undergoes rigorous testing, including HPLC for chemical purity and MS analysis to confirm isotopic enrichment and purity. Certificates of Analysis (COA) detailing batch-specific results for identity, assay, and isotopic purity are provided to ensure traceability and compliance with GLP/GMP guidelines.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as indicated on the label or COA. This material is hygroscopic (moisture-sensitive) and must be kept in a dry environment. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to expected mass
Purity (HPLC)	≥ 98.0%
Isotopic Purity (D6)	≥ 98.0 atom % D
Chemical Purity	≥ 95.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.