Description

Dantrolene-13C3 CAS NO 1185234-99-4 is a stable isotope-labeled analog of the skeletal muscle relaxant Dantrolene, where three carbon atoms are replaced with the 13C isotope. This compound is essential as an internal standard in quantitative bioanalytical methods, ensuring the highest accuracy and reliability in mass spectrometry-based analyses. It is primarily required by pharmaceutical research laboratories, contract research organizations (CROs), and diagnostic developers for pharmacokinetic studies, therapeutic drug monitoring, and metabolite identification.

Application

• Quantitative Bioanalysis: Serves as a critical internal standard for the precise LC-MS/MS quantification of Dantrolene and its metabolites in biological matrices like plasma, serum, and urine.
• Pharmacokinetic/Pharmacodynamic (PK/PD) Studies: Enables accurate measurement of drug concentration-time profiles to determine absorption, distribution, metabolism, and excretion (ADME) parameters.
• Clinical Research & Therapeutic Drug Monitoring (TDM): Used in assay development to monitor drug levels in patients for efficacy and safety, particularly relevant for managing malignant hyperthermia.
• Metabolite Profiling and Identification: Aids in the structural elucidation of drug metabolites by providing a mass spectrometric reference point.
• Method Development and Validation: Essential for developing, optimizing, and validating robust analytical methods in compliance with GLP and FDA/EMA guidelines.
• Reference Material for Certified Standards: Acts as a high-purity calibrant for the preparation of certified reference materials (CRMs).

Basic Information

Product Name	Dantrolene-13C3
CAS No.	1185234-99-4
Molecular Formula	C14H8N4O5 (with three 13C atoms)
Molecular Weight	~ 332.25 g/mol (exact value upon request)
Synonyms	1-[[[5-(4-Nitrophenyl)-2-furanyl]methylene]amino]-2,4-imidazolidinedione-13C3; Dantrolene (13C3); Dantrolene-13C3 Internal Standard; Dantrolene Stable Isotope; Dantrolene-13C3 Standard; [13C3]-Dantrolene; Dantrium-13C3; Dantrolene (labeled with carbon-13)
EINECS	Contact for details

Quality Control

Every batch of Dantrolene-13C3 is manufactured and analyzed under strict quality systems. We guarantee high chemical and isotopic purity, supported by comprehensive analytical data including NMR, HPLC, and MS. Certificates of Analysis (COA) are provided with each shipment, detailing batch-specific results for identity, purity (HPLC), isotopic enrichment, and residual solvents, ensuring compliance with research and regulatory standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label or COA. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability.

Specification

Item	Specification
Appearance	Yellow to orange crystalline powder
Identification (HPLC-MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (13C3)	≥ 99 atom % 13C
Chemical Purity	≥ 95%
Residual Solvents (GC)	Meets ICH guidelines
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.