Description

7-Benzyloxy-n-Des{[2-(2-Hydroxy)Ethoxy]Ethyl} Quetiapine-D8 is a deuterated analog of a key quetiapine metabolite, designed for use as a high-purity internal standard in analytical chemistry. This compound is critical for ensuring the accuracy and reliability of quantitative analyses, particularly in pharmacokinetic and bioequivalence studies. It is primarily utilized by pharmaceutical R&D laboratories, contract research organizations (CROs), and analytical testing facilities that require precise and traceable reference materials for method development and validation.

Application

• Internal Standard for LC-MS/MS: Serves as a stable, isotopically-labeled internal standard for the precise quantification of quetiapine and its metabolites in biological matrices like plasma and serum.
• Pharmaceutical R&D: Essential for method development, validation, and quality control during the drug development process of antipsychotic medications.
• Bioanalytical Testing: Used in CROs and clinical laboratories for conducting pharmacokinetic (PK), toxicokinetic (TK), and bioequivalence (BE) studies with enhanced accuracy.
• Metabolite Profiling: Aids in the identification and quantification of specific metabolic pathways of quetiapine in preclinical and clinical research.
• Regulatory Submissions: Supports data packages submitted to regulatory bodies (e.g., FDA, EMA) by providing validated analytical methods with high-quality reference standards.
• Forensic and Clinical Toxicology: Can be employed in specialized assays for monitoring drug levels in therapeutic drug monitoring (TDM) or forensic investigations.

Basic Information

Product Name	7-Benzyloxy-n-Des{[2-(2-Hydroxy)Ethoxy]Ethyl} Quetiapine-D8
CAS No.	1185177-12-1
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	7-Benzyloxy-n-Des(2-(2-Hydroxyethoxy)ethyl) Quetiapine-d8; Deuterated Quetiapine Metabolite Standard; Quetiapine D8 Metabolite; 7-Benzyloxy Norquetiapine-d8; N-Desalkyl Quetiapine-d8 Derivative; 7-Benzyloxy-N-dealkylquetiapine-d8; Internal Standard for Quetiapine Assay-d8; 1185177-12-1 (CAS Registry Number)
EINECS	Contact for details

Quality Control

Every batch of our deuterated standards is produced and analyzed under strict quality protocols to ensure exceptional isotopic purity and chemical identity, which are non-negotiable for reliable analytical results. Our quality system is designed to meet the rigorous demands of pharmaceutical analysis. Certificates of Analysis (COA) are provided with each shipment, detailing batch-specific results for identity, purity (by HPLC), isotopic enrichment, and other critical parameters.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as indicated on the label or COA. This product is hygroscopic (moisture-sensitive). Keep the container tightly sealed in a dry environment to prevent degradation from moisture absorption.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Isotopic Purity (D8)	≥ 98.0 atom % D
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.