Description

5-Chlorouracil-15N2,13C is a stable isotope-labeled derivative of the uracil nucleobase, specifically enriched with carbon-13 and nitrogen-15 at key positions. This compound is essential for advanced analytical research, providing an internal standard for precise quantification and metabolic pathway tracing in mass spectrometry. It is primarily utilized by researchers and manufacturers in the pharmaceutical, agrochemical, and life science sectors for drug metabolism studies (DMPK), proteomics, and the development of labeled active pharmaceutical ingredients (APIs).

Application

• Internal standard for the accurate quantification of 5-chlorouracil and related metabolites in biological matrices via LC-MS/MS and GC-MS.
• Tracer compound in drug metabolism and pharmacokinetics (DMPK) studies to elucidate metabolic pathways.
• Critical reagent in the synthesis of isotopically labeled nucleosides, nucleotides, and oligonucleotides for research.
• Use in proteomics and biomarker discovery as a stable isotope tag.
• Precursor for the development of labeled pharmaceutical compounds and agrochemicals for environmental fate studies.
• Tool compound in mechanistic biochemical research involving uracil metabolism and DNA/RNA interaction studies.

Basic Information

Product Name	5-Chlorouracil-15N2,13C
CAS No.	1185171-08-7
Molecular Formula	C413C H3 Cl N152 O2
Molecular Weight	~149.48 g/mol (for 13C, 15N2 labeled form)
Synonyms	5-Chloro-2,4(1H,3H)-pyrimidinedione-15N2,13C; 5-Chlorouracil-13C,15N2; Isotopically labeled 5-chlorouracil; 5-Cl-uracil-15N2,13C; [13C,15N2]-5-Chlorouracil; 5-Chloro-1H-pyrimidine-2,4-dione-15N2,13C; 5-Chlorouracil (13C, 15N2)
EINECS	Contact for details

Quality Control

Our 5-Chlorouracil-15N2,13C is manufactured under strict quality systems. Each batch undergoes rigorous analytical testing to ensure high chemical purity and isotopic enrichment, with specifications typically meeting or exceeding 98% chemical purity (HPLC) and 99% isotopic purity (atom % 13C and 15N). Certificates of Analysis (COA) detailing batch-specific results for assay, isotopic enrichment, and impurities are provided and available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This material is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere or in a controlled environment to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (13C)	≥ 99 atom %
Isotopic Purity (15N)	≥ 99 atom %
Chemical Purity (NMR)	Conforms
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.