Description

Norfluoxetine-D5 Hydrochloride is a deuterated internal standard of the selective serotonin reuptake inhibitor (SSRI) fluoxetine, specifically labeled with five deuterium atoms. This compound is essential for ensuring the accuracy and reliability of quantitative analytical methods, particularly in pharmacokinetic and bioequivalence studies. It is a critical tool for pharmaceutical R&D, clinical laboratories, and forensic toxicology departments requiring precise measurement of fluoxetine and its metabolites.

Application

• Internal Standard for LC-MS/MS: Primary use as a stable, isotopically labeled internal standard for the quantitative analysis of fluoxetine and norfluoxetine in biological matrices (plasma, serum, urine).
• Pharmaceutical Research & Development: Used in method development and validation for drug metabolism and pharmacokinetics (DMPK) studies of SSRIs.
• Clinical Toxicology & Therapeutic Drug Monitoring (TDM): Enables precise quantification of fluoxetine levels in patient samples to optimize dosing and ensure therapeutic efficacy.
• Forensic Analysis: Supports accurate detection and quantification of fluoxetine in post-mortem and forensic investigations.
• Reference Standard: Serves as a high-purity certified reference material (CRM) for calibrating analytical instrumentation.
• Metabolite Studies: Facilitates research into the metabolic pathways and clearance of fluoxetine.

Basic Information

Product Name	Norfluoxetine-D5 Hydrochloride
CAS No.	1185132-92-6
Molecular Formula	C16H11D5ClF3NO
Molecular Weight	341.80 g/mol
Synonyms	Norfluoxetine-d5 HCl; (R/S)-Norfluoxetine-d5 Hydrochloride; N-Desmethylfluoxetine-d5 Hydrochloride; 3-Phenyl-3-[(α,α,α-trifluoro-p-tolyl)oxy]propyl(methyl-d3)amine-d2 Hydrochloride; LY-110140-d5 Metabolite; Fluoxetine-d5 Metabolite HCl; (±)-Norfluoxetine-d5 Hydrochloride
EINECS	Contact for details

Quality Control

Every batch of Norfluoxetine-D5 Hydrochloride is manufactured under strict quality management systems and undergoes comprehensive analytical testing. We provide a detailed Certificate of Analysis (COA) with each shipment, confirming identity, chemical purity, isotopic purity (enrichment), and chromatographic profile. Our quality commitment ensures the material meets the stringent requirements for use as a certified reference standard in regulated environments.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as indicated on the label or COA. This material is hygroscopic (moisture-sensitive) and should be handled in a dry environment to maintain stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (Enrichment)	≥ 98 atom % D
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.