Description

4-Carboxytolbutamide-D9 Methyl Ester is a high-purity, deuterated isotopologue of a key pharmaceutical intermediate. This compound is specifically designed for use as an internal standard in quantitative mass spectrometry, providing superior accuracy and reliability in analytical workflows. It is essential for researchers and quality control laboratories in the pharmaceutical and contract research organization (CRO) sectors who require precise measurement of tolbutamide and related metabolites in complex biological matrices.

Application

• Internal Standard for LC-MS/MS: Primary application as a stable, isotopically labeled internal standard for the accurate quantification of tolbutamide in pharmacokinetic and bioanalytical studies.
• Pharmaceutical R&D: Used in drug metabolism and pharmacokinetics (DMPK) research to track the absorption, distribution, metabolism, and excretion (ADME) of sulfonylurea drugs.
• Clinical Toxicology: Supports method development and validation for the analysis of therapeutic drugs and their metabolites in patient samples.
• Reference Material: Serves as a certified reference material (CRM) for calibrating analytical instruments and ensuring method compliance with regulatory guidelines like FDA and EMA.
• Metabolite Synthesis: Acts as a key synthetic precursor for the preparation of deuterated metabolites of tolbutamide for further biological testing.

Basic Information

Product Name	4-Carboxytolbutamide-D9 Methyl Ester
CAS No.	1185126-97-9
Molecular Formula	C13H9D9N2O4S
Molecular Weight	295.38 g/mol
Synonyms	1-Butyl-3-(p-carboxymethylphenyl)sulfonylurea-D9 Methyl Ester; Tolbutamide-d9 Carboxylic Acid Methyl Ester; Methyl 4-[[[[(Butyl-d9)amino]carbonyl]amino]sulfonyl]benzoate; 4-Carboxytolbutamide Methyl Ester-d9; Deuterated Tolbutamide Carboxylic Acid Methyl Ester; 1-(Butyl-d9)-3-(4-(methoxycarbonyl)phenyl)sulfonylurea; Internal Standard for Tolbutamide LC-MS
EINECS	Contact for details

Quality Control

Every batch of 4-Carboxytolbutamide-D9 Methyl Ester is manufactured under strict quality management systems and undergoes comprehensive analytical characterization. We guarantee high chemical and isotopic purity to meet the exacting standards of modern bioanalysis. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting identity, purity (by HPLC), isotopic enrichment (by MS), and other critical parameters.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a dry environment. For long-term storage, consider storing at 2-8°C. Keep the container sealed to prevent moisture absorption.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥98.0%
Isotopic Purity (Deuterium Enrichment)	≥98.0 atom % D
Water Content (KF)	≤0.5%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.