Description

n-(2,3-Dichlorophenyl)Piperazine-D8 is a high-purity, deuterated analog of a key piperazine-based pharmaceutical intermediate, offering a stable isotopic label for advanced research and development. This compound is critical for metabolic and pharmacokinetic studies, providing enhanced detection sensitivity and reliability in analytical methods. It is primarily required by pharmaceutical R&D laboratories, contract research organizations (CROs), and manufacturers of active pharmaceutical ingredients (APIs) for use in drug discovery and development programs.

Application

• As a stable isotopically labeled internal standard for the quantitative analysis of its non-deuterated counterpart in biological matrices using LC-MS/MS.
• In pharmacokinetic (PK) and drug metabolism studies to track the absorption, distribution, metabolism, and excretion (ADME) of lead compounds.
• For use in deuterium labeling chemistry to modify the properties of drug candidates, potentially improving metabolic stability.
• As a key reference material in the quality control and method validation processes for API manufacturing.
• In academic and industrial research focused on the synthesis and biological evaluation of novel piperazine-containing molecules.

Basic Information

Product Name	n-(2,3-Dichlorophenyl)Piperazine-D8
CAS No.	1185116-86-2
Molecular Formula	C10H4D8Cl2N2
Molecular Weight	247.20 g/mol (deuterated form)
Synonyms	1-(2,3-Dichlorophenyl)piperazine-d8; 2,3-Dichloro-N-piperazinyl-d8-aniline; Deuterated 1-(2,3-Dichlorophenyl)piperazine; D8-1-(2,3-DCPP); (2,3-Dichlorophenyl)piperazine-d8; 1-(2,3-Dichlorophenyl)-1,2,3,4,5,6,7,8-octadeuterioperhydro-1,4-diazine; 1-(2,3-Dichlorophenyl)piperazine (octadeuterated)
EINECS	Contact for details

Quality Control

Our deuterated compounds are produced under strict quality control protocols to ensure isotopic purity and chemical integrity. Each batch is characterized by advanced spectroscopic and chromatographic techniques, including NMR, HPLC, and mass spectrometry. Certificates of Analysis (COA) are provided, detailing isotopic enrichment (typically ≥98 atom % D), chemical purity (≥95% by HPLC), and confirming structural identity. We adhere to cGMP principles where applicable to support regulatory filings.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive); ensure the container is sealed under an inert atmosphere after each use to prevent degradation. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Isotopic Purity (NMR/MS)	≥ 98 atom % D
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.