Description

Hydroxy Tolbutamide-D9 is a high-purity, deuterium-labeled internal standard critical for advanced analytical chemistry. This compound is essential for ensuring the accuracy and reliability of quantitative mass spectrometry analyses, particularly in pharmacokinetic and metabolic studies. It is primarily utilized by pharmaceutical R&D laboratories, contract research organizations (CROs), and analytical testing facilities requiring precise bioanalytical method development and validation.

Application

• Used as a stable isotope-labeled internal standard for the quantitative analysis of Tolbutamide and its metabolites via LC-MS/MS and GC-MS.
• Essential in pharmaceutical research for conducting accurate pharmacokinetic (PK) and bioavailability studies.
• Critical for drug metabolism and disposition (DMPK) investigations to track and quantify metabolic pathways.
• Supports bioanalytical method development and validation in compliance with FDA and ICH guidelines.
• Enables high-precision clinical and pre-clinical assay development for diabetes-related therapeutics.
• Applied in forensic toxicology for the definitive identification and quantification of sulfonylurea compounds.

Basic Information

Product Name	Hydroxy Tolbutamide-D9
CAS No.	1185112-19-9
Molecular Formula	C12H9D9N2O4S
Molecular Weight	287.38 g/mol
Synonyms	1-Butyl-3-[(4-hydroxyphenyl)sulfonyl]-1-(trideuteriomethyl)(2H3)urea; 4-Hydroxy Tolbutamide-d9; 1-(p-Hydroxyphenylsulfonyl)-3-butyl-3-(methyl-d3)urea; Deuterated Hydroxy Tolbutamide; Tolbutamide Metabolite-d9; Hydroxy Tolbutamide Deuterated Standard; Hydroxytolbutamide-d9; [D9]-4-Hydroxytolbutamide
EINECS	Contact for details

Quality Control

Our Hydroxy Tolbutamide-D9 is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, NMR, and mass spectrometry, to ensure isotopic purity and chemical identity. A detailed Certificate of Analysis (COA) is provided, confirming compliance with specifications for use as a reference standard. We support traceability and data integrity requirements for GLP and cGMP environments.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a dry, cool place. This material is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥98.0%
Isotopic Purity	≥99.0 atom % D
Chemical Purity	≥95.0%
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.