Description

Rabeprazole-D3 Sulfide is a deuterated isotopologue of a key intermediate in the synthesis of the proton pump inhibitor rabeprazole. This compound is specifically designed for use as an internal standard in analytical chemistry, providing unmatched accuracy and reliability for quantitative analysis. It is essential for researchers and quality control laboratories in the pharmaceutical industry who require precise measurement of rabeprazole and its metabolites in complex matrices such as biological fluids and drug formulations.

Application

• Pharmaceutical Reference Standard: Serves as a critical internal standard in Liquid Chromatography-Mass Spectrometry (LC-MS) and Gas Chromatography-Mass Spectrometry (GC-MS) for the quantification of rabeprazole.
• Drug Metabolism and Pharmacokinetics (DMPK) Studies: Enables accurate tracking and measurement of rabeprazole and its metabolites in preclinical and clinical studies.
• Bioanalytical Method Development: Used to validate analytical methods for rabeprazole in accordance with regulatory guidelines (e.g., FDA, EMA).
• Impurity Profiling and Characterization: Assists in the identification and quantification of process-related impurities and degradation products in rabeprazole API and finished dosage forms.
• Stability-Indicating Assays: Provides a stable isotopic marker for developing robust assays that monitor rabeprazole stability under various stress conditions.
• Clinical Research: Supports therapeutic drug monitoring and bioavailability/bioequivalence studies for rabeprazole-based medications.

Basic Information

Product Name	Rabeprazole-D3 Sulfide
CAS No.	1185084-49-4
Molecular Formula	C18H18D3N3O2S
Molecular Weight	340.46 g/mol
Synonyms	2-[[[4-(3-Methoxypropoxy)-3-methyl-2-pyridinyl]methyl]sulfinyl]-1H-benzimidazole-d3; Rabeprazole Sulfide-d3; Rabeprazole Intermediate-d3; Deuterated Rabeprazole Sulfide; 1H-Benzimidazole, 2-[[[4-(3-methoxypropoxy)-3-methyl-2-pyridinyl]methyl]sulfinyl]-, labeled with deuterium; Rabeprazole-d3 Sulfide (Isotopic Labeled Standard)
EINECS	Contact for details

Quality Control

Our Rabeprazole-D3 Sulfide is manufactured under strict quality control protocols to ensure the highest isotopic purity and chemical integrity required for analytical applications. Each batch is characterized using advanced techniques including NMR, HPLC, and Mass Spectrometry to confirm identity, chemical purity, and isotopic enrichment. A comprehensive Certificate of Analysis (COA) is provided, detailing all critical parameters. Our quality system is designed to support compliance with cGMP and ICH guidelines for reference standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept in a desiccated environment to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (Deuterium Content)	≥ 98.0 atom % D
Chemical Purity (by HPLC)	≥ 99.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.