Description

Raloxifene-D4 is a deuterium-labeled analog of the selective estrogen receptor modulator (SERM) raloxifene, specifically designed for use as an internal standard in quantitative analytical methods. This high-purity, isotopically labeled compound is essential for ensuring the accuracy and reliability of mass spectrometry-based analyses in pharmaceutical research and development. It is primarily utilized by analytical chemists and researchers in pharmaceutical companies, contract research organizations (CROs), and academic institutions engaged in drug metabolism, pharmacokinetic (DMPK) studies, and bioanalytical method validation.

Application

• Internal Standard for LC-MS/MS: Serves as a critical internal standard for the precise quantification of raloxifene and its metabolites in complex biological matrices such as plasma, serum, and tissue homogenates.
• Drug Metabolism and Pharmacokinetics (DMPK): Enables accurate tracking of drug absorption, distribution, metabolism, and excretion (ADME) profiles in preclinical and clinical studies.
• Bioanalytical Method Development and Validation: Used to develop, optimize, and validate robust HPLC and UPLC methods coupled with mass spectrometry, improving assay precision and compensating for matrix effects.
• Clinical Research and Therapeutic Drug Monitoring (TDM): Supports studies investigating the efficacy and safety profiles of raloxifene, facilitating reliable patient sample analysis.
• Pharmaceutical Quality Control: Aids in impurity profiling and stability testing of raloxifene-based drug formulations.
• Forensic and Anti-Doping Analysis: Applicable in specialized testing environments for the definitive identification and quantification of related compounds.

Basic Information

Product Name	Raloxifene-D4
CAS No.	1185076-44-1
Molecular Formula	C28H23D4NO4S
Molecular Weight	477.60 g/mol (deuterated form)
Synonyms	Raloxifene-d4; [2H4]-Raloxifene; 6-Hydroxy-2-(4-hydroxyphenyl)benzo[b]thien-3-yl-4-[2-(1-piperidinyl)ethoxy]phenyl-d4 Methanone; LY156758-d4; Keoxifene-d4; Evista-d4 (labeled analog); (6-Hydroxy-2-(4-hydroxyphenyl)benzo[b]thien-3-yl)(4-[2-(piperidin-1-yl)ethoxy]phenyl-d4)methanone
EINECS	Contact for details

Quality Control

Every batch of Raloxifene-D4 is manufactured and analyzed under strict quality management systems. We guarantee high chemical and isotopic purity, supported by comprehensive analytical data including NMR, HPLC, and mass spectrometry. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting the deuterium enrichment (atom % D), purity by HPLC, and confirming the absence of unlabeled raloxifene. Our quality processes are designed to meet the rigorous standards required for GLP (Good Laboratory Practice) and GMP (Good Manufacturing Practice) compliant research.

Storage

Preserve in a tightly closed container, protected from light. Store at 2-8°C or as indicated on the label or COA. This product is hygroscopic (moisture-sensitive). For long-term storage, consider desiccation and storage under an inert atmosphere to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC-MS)	Conforms to structure
Purity (HPLC)	≥98.0%
Isotopic Purity (Atom % D)	≥98.0% (by MS)
Chemical Purity (NMR)	Conforms
Water Content (KF)	≤1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.