Description

Clotrimazole-D5 is a deuterated analog of the widely used antifungal agent, clotrimazole, specifically labeled with five deuterium atoms. This stable isotope-labeled compound is an essential reference standard and internal standard for precise quantitative analysis in pharmaceutical research and development. It is primarily utilized by analytical laboratories and research institutions engaged in pharmacokinetic studies, drug metabolism research, and quality control testing of antifungal formulations. The product ensures high accuracy and reliability in mass spectrometry and other analytical techniques.

Application

• Primary use as an internal standard for the accurate quantification of clotrimazole in biological matrices using LC-MS/MS and GC-MS.
• Critical component in pharmacokinetic and bioequivalence studies to determine drug absorption, distribution, metabolism, and excretion.
• Reference material for method development and validation in analytical laboratories to ensure regulatory compliance (e.g., FDA, EMA).
• Used in drug metabolism and stability studies to track and identify metabolites.
• Essential for quality control and assurance in the manufacturing of antifungal pharmaceutical products.
• Tool in forensic and clinical toxicology for the precise detection and measurement of clotrimazole.

Basic Information

Product Name	Clotrimazole-D5
CAS No.	1185076-41-8
Molecular Formula	C22H12Cl5N2
Molecular Weight	349.71 g/mol (for unlabeled clotrimazole; contact for exact weight of D5 variant)
Synonyms	1-[(2-Chlorophenyl)(diphenyl)methyl]-1H-imidazole-d5; Clotrimazole-d5; Deuterated Clotrimazole; Clotrimazole (phenyl-d5); Bay-5097-d5; Lotrimin-d5 (labeled variant); Mycelex-d5 (labeled variant); Antifungal Agent-d5 (labeled)
EINECS	Contact for details

Quality Control

Our Clotrimazole-D5 is manufactured under strict quality systems to ensure the highest isotopic and chemical purity required for analytical applications. Each batch is characterized by advanced spectroscopic and chromatographic methods, including NMR, HPLC, and MS, to confirm identity, isotopic enrichment, and purity. A comprehensive Certificate of Analysis (COA) detailing batch-specific results is provided with every shipment. We support compliance with GMP/GLP guidelines for reference standard materials.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). This material is hygroscopic (moisture-sensitive); ensure the container is sealed tightly after each use to minimize exposure to atmospheric humidity. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0% (chemical purity)
Isotopic Purity (Deuterium Enrichment)	≥ 98.0 atom % D
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.