Description

Meclofenamic Acid-D4 is a stable isotope-labeled analog of the non-steroidal anti-inflammatory drug (NSAID) meclofenamic acid, where four hydrogen atoms are replaced by deuterium. This compound is an essential internal standard for the precise and accurate quantification of meclofenamic acid in complex biological matrices using advanced analytical techniques like LC-MS/MS. It is primarily required by pharmaceutical research laboratories, contract research organizations (CROs), and analytical testing facilities engaged in pharmacokinetic studies, drug metabolism research, and bioanalytical method development.

Application

• Internal Standard for Bioanalysis: Serves as a critical deuterated internal standard in the quantitative LC-MS/MS analysis of meclofenamic acid in plasma, serum, and other biological fluids.
• Drug Metabolism and Pharmacokinetics (DMPK): Used in studies to understand the absorption, distribution, metabolism, and excretion (ADME) profile of meclofenamic acid.
• Pharmaceutical R&D: Supports method development and validation for quality control and regulatory submissions in drug development pipelines.
• Clinical Research: Enables accurate therapeutic drug monitoring and biomarker analysis in clinical trial samples.
• Forensic and Anti-Doping Analysis: Applied in confirmatory testing protocols where precise measurement of NSAIDs is required.
• Stable Isotope Labeling Studies: Utilized in mechanistic studies to trace metabolic pathways and identify drug-derived metabolites.

Basic Information

Product Name	Meclofenamic Acid-D4
CAS No.	1185072-18-7
Molecular Formula	C14H7D4Cl2NO2
Molecular Weight	298.17 g/mol (approx.)
Synonyms	2-[(2,6-Dichloro-3-methylphenyl)amino]-3-(deuteriomethyl)benzoic-3,4,5,6-d4 acid; Meclofenamic Acid (D4); Deuteronated Meclofenamic Acid; Meclofenamic-d4 Acid; N-(2,6-Dichloro-m-tolyl)anthranilic Acid-D4; Arquel-d4; CL-583-d4
EINECS	Contact for details

Quality Control

Our Meclofenamic Acid-D4 is manufactured under strict quality control protocols to ensure the highest isotopic purity and chemical integrity required for sensitive analytical applications. Each batch is characterized by advanced spectroscopic and chromatographic methods, including NMR, HPLC, and MS, to confirm isotopic enrichment and chemical purity. A comprehensive Certificate of Analysis (COA) detailing batch-specific results for assay, isotopic purity, and impurity profile is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); ensure the container is sealed tightly after each use to minimize exposure to atmospheric humidity. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥98.0%
Isotopic Purity (NMR/MS)	≥98.0 atom % D
Chemical Purity	≥95.0%
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.