Description

Rac 5-Hydroxymethyl Tolterodine-D14 CAS NO 1185071-13-9 is a deuterium-labeled isotopologue of a key tolterodine intermediate, serving as a critical internal standard for precise analytical quantification. This compound is essential for ensuring accuracy and reliability in pharmaceutical research and development, particularly in pharmacokinetic and metabolic studies. It is primarily used by analytical chemists, researchers, and quality control laboratories in the pharmaceutical and contract research organization (CRO) sectors.

Application

• Internal Standard for LC-MS/MS: Used as a stable, isotopically labeled reference standard in Liquid Chromatography-Mass Spectrometry for the accurate quantification of tolterodine and its metabolites in biological matrices.
• Pharmacokinetic (PK) Studies: Enables precise tracking and measurement of drug absorption, distribution, metabolism, and excretion (ADME) profiles in preclinical and clinical research.
• Bioanalytical Method Development & Validation: Critical for developing and validating robust, sensitive, and specific analytical methods compliant with FDA and ICH guidelines.
• Drug Metabolism Research: Facilitates the study of metabolic pathways and the identification of metabolites, aiding in drug safety and efficacy evaluations.
• Quality Control & Assurance: Employed in pharmaceutical manufacturing for batch-to-batch consistency testing and impurity profiling of active pharmaceutical ingredients (APIs).
• Reference Material for Certified Standards: Serves as a high-purity starting material for the preparation of certified reference materials (CRMs).

Basic Information

Item	Detail
Product Name	Rac 5-Hydroxymethyl Tolterodine-D14
CAS No.	1185071-13-9
Molecular Formula	C22H17D14NO2
Molecular Weight	~ 351.56 g/mol
Synonyms	5-(Hydroxymethyl)-2-[(1R)-3-[bis(1-methylethyl)amino]-1-phenylpropyl]-4-methylphenyl-d14 3,5-Dihydroxybenzoate; Tolterodine-d14 Hydroxymethyl Intermediate; (Rac)-5-Hydroxymethyl Tolterodine-d14; Deuterated Tolterodine Hydroxymethyl Metabolite; Isotopically Labeled Tolterodine Precursor; 5-HMT-d14; Tolterodine-d14 Alcohol
EINECS	Contact for details

Quality Control

Our Rac 5-Hydroxymethyl Tolterodine-D14 is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure high chemical and isotopic purity, meeting the stringent requirements for use as an internal standard. Certificates of Analysis (COA) detailing purity, isotopic enrichment, and all analytical results are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container should be kept in a desiccated environment. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (D-enrichment)	≥ 98.0 atom % D
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.