Description

Bexarotene-13C4 is a stable isotope-labeled analog of the synthetic retinoid Bexarotene, specifically enriched with four carbon-13 atoms at key molecular positions. This compound is essential for use as an internal standard in quantitative mass spectrometry, providing unmatched accuracy and reliability for pharmacokinetic and metabolic studies. It is a critical tool for pharmaceutical R&D, clinical research, and bioanalytical laboratories focused on oncology drug development and therapeutic monitoring.

Application

• Internal Standard for LC-MS/MS: Primary application as a high-purity, isotopically labeled internal standard for the precise quantification of Bexarotene and its metabolites in complex biological matrices like plasma, serum, and tissue homogenates.
• Pharmacokinetic (PK) Studies: Enables accurate determination of drug absorption, distribution, metabolism, and excretion (ADME) profiles in preclinical and clinical research.
• Metabolite Identification & Profiling: Facilitates the detection and structural elucidation of drug metabolites, aiding in the understanding of metabolic pathways.
• Bioanalytical Method Development & Validation: Used to develop, optimize, and validate robust analytical methods in compliance with FDA, EMA, and ICH guidelines (e.g., ICH M10).
• Drug-Drug Interaction Studies: Supports research into how Bexarotene interacts with other co-administered pharmaceuticals.
• Quality Control in Manufacturing: Can be employed in the quality control of active pharmaceutical ingredient (API) batches for Bexarotene.

Basic Information

Product Name	Bexarotene-13C4
CAS No.	1185030-01-6
Molecular Formula	C13C20H20O2
Molecular Weight	352.42 g/mol (approx.)
Synonyms	4-[1-(5,6,7,8-Tetrahydro-3,5,5,8,8-pentamethyl-2-naphthalenyl)ethenyl]benzoic acid-13C4; LGD1069-13C4; Targretin-13C4; Isotopically Labeled Bexarotene; Bexarotene (13C4); [13C4]-Bexarotene; 13C4-Bexarotene
EINECS	Contact for details

Quality Control

Our Bexarotene-13C4 is manufactured under strict quality systems to ensure the highest isotopic and chemical purity required for sensitive bioanalytical applications. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing results for isotopic purity (≥99 atom % 13C), chemical purity (by HPLC), and identity confirmation (by NMR and MS). We adhere to relevant industry standards for reference materials.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry, cool place. This product is hygroscopic (moisture-sensitive). For long-term storage, consider storing under an inert atmosphere. Allow the vial to equilibrate to room temperature before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥98.0%
Isotopic Purity	≥99 atom % 13C
Chemical Purity	≥95%
Water Content (KF)	≤1.0%
Residual Solvents (GC)	Complies with ICH Q3C

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.