Description

Bromazepam-D4 is a deuterated analog of the pharmaceutical compound Bromazepam, specifically designed for use as an internal standard in analytical chemistry. This high-purity, isotopically labeled compound is essential for ensuring the accuracy and reliability of quantitative mass spectrometry analyses. It is primarily utilized by pharmaceutical research laboratories, forensic toxicology departments, and contract research organizations (CROs) for method development, drug metabolism studies, and precise quantification of Bromazepam in complex biological matrices.

Application

• Internal Standard for LC-MS/MS: Serves as a critical reference compound for the accurate quantification of Bromazepam in pharmacokinetic and bioequivalence studies.
• Forensic and Clinical Toxicology: Used in the development and validation of analytical methods for detecting and measuring Bromazepam in blood, urine, and other biological samples.
• Drug Metabolism and Pharmacokinetics (DMPK): Enables precise tracking of the parent drug and its metabolites in in vitro and in vivo studies.
• Pharmaceutical Quality Control: Supports impurity profiling and assay validation for drug substance and finished product testing.
• Reference Material for Method Development: Provides a stable, non-interfering signal for optimizing liquid chromatography and mass spectrometry parameters.
• Research on Benzodiazepine Pharmacology: Facilitates advanced research into the absorption, distribution, metabolism, and excretion (ADME) profiles of benzodiazepine-class drugs.

Basic Information

Product Name	Bromazepam-D4
CAS No.	1185022-85-8
Molecular Formula	C14H6D4BrN2O
Molecular Weight	317.18 g/mol
Synonyms	7-Bromo-5-(pyridin-2-yl)-1,3-dihydro-2H-1,4-benzodiazepin-2-one-d4; 7-Bromo-1,3-dihydro-5-(2-pyridinyl)-2H-1,4-benzodiazepin-2-one-d4; Deuterated Bromazepam; Bromazepam (phenyl-d4); Lexotanil-d4; Lexotan-d4; Lectopam-d4
EINECS	Contact for details

Quality Control

Every batch of Bromazepam-D4 is manufactured and analyzed under strict quality management protocols to ensure exceptional isotopic purity and chemical integrity. Our products undergo rigorous quality testing, including advanced spectroscopic and chromatographic methods, to ensure compliance with the stringent requirements for analytical reference standards. A comprehensive Certificate of Analysis (COA) detailing isotopic enrichment, chemical purity, and analytical results is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to maintain stability and purity. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (D-content)	≥ 98.0 atom % D
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.