Description

Homovanillic Acid-13C6 is a stable isotope-labeled analog of homovanillic acid, where six carbon atoms are replaced with the 13C isotope. This compound is essential as a high-purity internal standard for the accurate quantification of homovanillic acid in complex biological matrices using mass spectrometry. It is primarily required by analytical laboratories and research institutions in the fields of neuroscience, clinical diagnostics, and pharmaceutical development for precise biomarker analysis and method validation.

Application

• Internal Standard for LC-MS/MS: Used as a quantitative reference in liquid chromatography-tandem mass spectrometry (LC-MS/MS) assays for homovanillic acid.
• Biomarker Research: Critical for studying catecholamine metabolism, particularly in research related to Parkinson's disease, neuroblastoma, and other neurological disorders.
• Clinical Diagnostics: Enables precise measurement of homovanillic acid levels in urine, plasma, and cerebrospinal fluid for diagnostic purposes.
• Pharmaceutical Development: Supports pharmacokinetic and metabolomic studies during drug development targeting the dopaminergic system.
• Forensic Toxicology: Applied in analytical methods for the detection and quantification of dopamine metabolites in forensic casework.
• Quality Control in Reference Material Production: Serves as a calibrant in the manufacture of certified reference materials (CRMs) for clinical laboratories.

Basic Information

Product Name	Homovanillic Acid-13C6
CAS No.	1185016-45-8
Molecular Formula	C913C6H10O4
Molecular Weight	198.13 g/mol (for 13C6 labeled form)
Synonyms	4-Hydroxy-3-methoxybenzeneacetic acid-13C6; 3-Methoxy-4-hydroxyphenylacetic acid-13C6; HVA-13C6; 4-Hydroxy-3-methoxyphenylacetic acid-13C6; (4-Hydroxy-3-methoxyphenyl)acetic acid-13C6; Vanillacetic acid-13C6; Isotopically labeled homovanillic acid
EINECS	Contact for details

Quality Control

Every batch of Homovanillic Acid-13C6 is manufactured and analyzed under strict quality management systems to ensure exceptional isotopic purity and chemical integrity. Our products undergo rigorous quality testing, including advanced spectroscopic and chromatographic methods, to ensure compliance with research and diagnostic standards. Certificates of Analysis (COA) detailing isotopic enrichment, chemical purity, and analytical results are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at 2-8°C. This material is hygroscopic (moisture-sensitive) and should be kept in a cool, dry place. For long-term storage, consider desiccation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98%
Isotopic Enrichment	≥ 99 atom % 13C
Chemical Purity	≥ 95%
Water Content (KF)	≤ 1.0%
Solubility	Soluble in methanol, DMSO; slightly soluble in water

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.