Description

Raloxifene-D4 Bismethyl Ether is a deuterated analog of a key pharmaceutical intermediate, specifically designed for use as an internal standard in advanced analytical chemistry. This high-purity compound is critical for ensuring the accuracy and reliability of quantitative analyses, particularly in pharmacokinetic and metabolic studies. It is an essential material for pharmaceutical R&D laboratories, contract research organizations (CROs), and analytical service providers focused on method development and quality control for selective estrogen receptor modulators (SERMs).

Application

• Internal Standard for LC-MS/MS: Primary use as a stable, isotopically labeled internal standard for the precise quantification of Raloxifene and related metabolites in complex biological matrices like plasma and tissue homogenates.
• Pharmaceutical Research & Development: Supports method development, validation, and bioanalytical studies during drug discovery and preclinical/clinical trials for SERM-based therapies.
• Metabolite Identification & Tracing: Facilitates advanced mass spectrometry studies for tracking drug distribution, metabolism, and excretion pathways due to its isotopic signature.
• Quality Control & Assurance: Used in analytical laboratories to develop and run high-accuracy assays for raw material and finished product testing in pharmaceutical manufacturing.
• Reference Material for Regulatory Submissions: Provides a certified reference material to support data packages submitted to regulatory bodies like the FDA and EMA.

Basic Information

Item	Details
Product Name	Raloxifene-D4 Bismethyl Ether
CAS No.	1185006-58-9
Molecular Formula	C28H23D4NO4S
Molecular Weight	477.59 g/mol (approx.)
Synonyms	6-Hydroxy-2-(4-hydroxyphenyl)benzo[b]thien-3-yl 4-[2-(1-Piperidinyl)ethoxy]phenyl-d4 Methanone Bismethyl Ether; Raloxifene-d4 Dimethyl Ether; [D4]-Raloxifene Bismethyl Ether; Raloxifene Methyl Ether-d4; Deuterated Raloxifene Intermediate; Isotopically Labeled Raloxifene Derivative; SERM Internal Standard-d4
EINECS	Contact for details

Quality Control

Every batch of Raloxifene-D4 Bismethyl Ether is manufactured under strict quality management systems and undergoes comprehensive analytical characterization. We guarantee high chemical and isotopic purity, confirmed by techniques including NMR, HPLC, and mass spectrometry. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting purity, isotopic enrichment, and other critical specifications to support your regulatory and research requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled in a dry environment to maintain stability and purity. For long-term storage, consider desiccant use.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (deuterium enrichment)	≥ 98.0 atom % D
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.