Description

Losartan Carboxaldehyde-D3 is a deuterium-labeled derivative of a key intermediate in the synthesis of Losartan, a widely prescribed angiotensin II receptor antagonist. This high-purity, isotopically labeled compound is essential for conducting precise and reliable pharmacokinetic and metabolic studies, ensuring accurate quantification and traceability in research. It is primarily utilized by pharmaceutical R&D laboratories, contract research organizations (CROs), and analytical service providers engaged in drug development and bioanalytical method validation.

Application

• Internal Standard for LC-MS/MS Analysis: Serves as a critical internal standard for the quantitative bioanalysis of Losartan and its metabolites in biological matrices like plasma and urine.
• Drug Metabolism and Pharmacokinetics (DMPK) Studies: Enables accurate tracing of the parent drug's absorption, distribution, metabolism, and excretion (ADME) profile in preclinical and clinical research.
• Stable Isotope Labeling in Synthesis: Used as a labeled building block in the synthesis of deuterated drug candidates for mechanistic studies.
• Biomedical Research: Facilitates in-vitro and in-vivo studies to understand drug-drug interactions and metabolic pathways.
• Quality Control and Method Development: Employed in analytical laboratories for developing and validating robust HPLC and mass spectrometry methods for pharmaceutical quality assurance.

Basic Information

Product Name	Losartan Carboxaldehyde-D3
CAS No.	1184999-26-5
Molecular Formula	C22H20D3ClN6O
Molecular Weight	425.94 g/mol
Synonyms	2-Butyl-5-chloro-3-[[[2'-(2H3)methyl[1,1'-biphenyl]-4-yl]methyl]carbamoyl]-1H-imidazole-4-carboxaldehyde; Losartan Aldehyde-D3; 2-n-Butyl-5-chloro-3-[[[2'-(2H3)methyl[1,1'-biphenyl]-4-yl]methyl]carbamoyl]-1H-imidazole-4-carboxaldehyde; EXP 3174 Aldehyde-D3; Losartan Carboxaldehyde (methyl-D3); Deuterated Losartan Aldehyde; [2H3]-Losartan Carboxaldehyde
EINECS	Contact for details

Quality Control

Our Losartan Carboxaldehyde-D3 is manufactured under strict quality control protocols to ensure exceptional isotopic purity and chemical integrity, suitable for sensitive analytical applications. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing results for isotopic enrichment (D-content), chemical purity (by HPLC), and identification. We adhere to relevant industry standards for high-purity reference materials to support GLP-compliant research.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (D-content)	≥ 98.0 atom % D
Chemical Purity	≥ 95.0%
Water Content (KF)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.