Description

2-Bromo-1-(4'-Methoxy-3'-Sulfonamidophenyl)-1-Propanone-Methyl-D3 is a high-purity, deuterated organic intermediate of significant importance in advanced chemical synthesis. This compound matters for its role as a critical building block in the development of isotopically labeled active pharmaceutical ingredients (APIs) and other fine chemicals, enabling precise metabolic and pharmacokinetic studies. Pharmaceutical R&D laboratories, contract research organizations (CROs), and specialty chemical manufacturers need this material for synthesizing novel drug candidates and analytical reference standards.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of deuterated drug molecules for improved metabolic stability and reduced toxicity profiles.
• Isotope Labeling Agent: Used to incorporate deuterium (D) atoms into target molecules for use in Mass Spectrometry (MS) and Nuclear Magnetic Resonance (NMR) studies.
• Metabolic Research: Enables the tracing of drug metabolites in biological systems, crucial for ADME (Absorption, Distribution, Metabolism, Excretion) studies.
• Reference Standard Development: Serves as a starting material for producing certified reference standards (CRS) and internal standards for quantitative bioanalysis.
• Medicinal Chemistry Research: Utilized in structure-activity relationship (SAR) studies to explore the impact of deuteration on biological activity.
• Process Chemistry: Employed in the scale-up and optimization of synthetic routes for deuterated active pharmaceutical ingredients (APIs).

Basic Information

Product Name	2-Bromo-1-(4'-Methoxy-3'-Sulfonamidophenyl)-1-Propanone-Methyl-D3
CAS No.	1184998-47-7
Molecular Formula	C11H10D3BrNO4S
Molecular Weight	Contact for details
Synonyms	2-Bromo-1-(4-methoxy-3-sulfamoylphenyl)propan-1-one-methyl-d3; 1-Propanone, 2-bromo-1-[4-methoxy-3-[(aminosulfonyl)amino]phenyl]-, methyl-d3; Deuterated 2-Bromo Propiophenone Sulfonamide Derivative; (4-Methoxy-3-sulfamoylphenyl)(2-bromo-1-oxopropyl-d3) Ketone; 2-Bromo-1-(3-sulfamoyl-4-methoxyphenyl)propan-1-one-methyl-d3
EINECS	Contact for details

Quality Control

Our 2-Bromo-1-(4'-Methoxy-3'-Sulfonamidophenyl)-1-Propanone-Methyl-D3 is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure high chemical purity, isotopic enrichment, and structural identity. Certificates of Analysis (COA) detailing all specifications are provided with every shipment to guarantee traceability and batch-to-batch consistency for your critical research and development projects.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Deuterium Enrichment (MS)	≥ 98 atom % D
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.