Description

n-(3-Mercapto-2-Methylpropanoyl)Glycine-D5 is a deuterated isotopologue of a key mercapto acid derivative, specifically engineered for use as an internal standard in advanced analytical chemistry. This high-purity compound is critical for ensuring the accuracy and reliability of quantitative analyses, particularly in mass spectrometry, by correcting for variations in sample preparation and instrument response. It is an essential tool for researchers and quality control laboratories in the pharmaceutical, biotechnology, and forensic science sectors who require precise measurement of related non-deuterated compounds.

Application

• Internal Standard for LC-MS/MS: Primary application for the accurate quantification of its non-deuterated counterpart or related metabolites in complex biological matrices like plasma, serum, and urine.
• Pharmaceutical R&D: Used in pharmacokinetic (PK) and pharmacodynamic (PD) studies to track drug metabolism and establish bioavailability with high precision.
• Biomarker Analysis: Enables reliable measurement of specific endogenous or exogenous thiol-containing compounds in clinical and diagnostic research.
• Metabolomics Research: Serves as a stable isotope-labeled reference compound in targeted metabolomic profiling to study biochemical pathways.
• Forensic Toxicology: Employed in confirmatory testing protocols for the precise determination of specific analytes in forensic samples.
• Method Development & Validation: Critical for developing, optimizing, and validating robust analytical methods in compliance with regulatory guidelines (e.g., FDA, EMA).

Basic Information

Product Name	n-(3-Mercapto-2-Methylpropanoyl)Glycine-D5
CAS No.	1184993-97-2
Molecular Formula	C7H6D5NO3S
Molecular Weight	~197.25 g/mol
Synonyms	N-(3-Mercapto-2-methyl-1-oxopropyl)glycine-d5; (2R)-2-Acetylthio-3-methylbutanoic-d5 acid glycine amide; 3-Mercapto-2-methylpropionylglycine-d5; Tiopronin-d5; Thiola-d5; α-Mercaptopropionylglycine-d5; MPG-d5; Deuterated Tiopronin
EINECS	Contact for details

Quality Control

Every batch of n-(3-Mercapto-2-Methylpropanoyl)Glycine-D5 is manufactured and tested under strict quality systems to meet the exacting requirements of analytical standard applications. We provide comprehensive Certificates of Analysis (COA) that detail isotopic purity (D-enrichment at specified positions), chemical purity by HPLC, and confirm structural identity via spectroscopic methods. Our quality commitment ensures consistency and reliability for your most sensitive research and compliance-driven work.

Storage

Preserve in a tightly closed container, protected from light. Store at 2-8°C under an inert atmosphere (e.g., argon or nitrogen) to minimize oxidation of the thiol group. Keep the container in a dry, cool, and well-ventilated place. For long-term storage, desiccate at -20°C.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (D-content)	≥ 98 atom % D
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.