Description

3-Ketovalproic Acid Sodium Salt is a key pharmaceutical intermediate and metabolite of the anticonvulsant drug valproic acid. This compound is of significant value for research and development in neuropharmacology and metabolic studies. It is primarily utilized by pharmaceutical companies, contract research organizations (CROs), and academic institutions engaged in drug metabolism and pharmacokinetics (DMPK) research, synthesis of novel valproate derivatives, and analytical method development.

Application

• Pharmaceutical Intermediate: Critical building block for the synthesis of novel valproic acid analogs and prodrugs.
• Metabolite Reference Standard: Essential for the identification and quantification of valproic acid metabolites in bioanalytical studies (DMPK) and clinical research.
• Biochemical Research: Used in studies investigating the mechanisms of action, metabolic pathways, and potential neuroprotective effects of valproate compounds.
• Analytical Method Development: Serves as a high-purity standard for calibrating HPLC, LC-MS, and GC-MS systems in pharmaceutical quality control and forensic toxicology labs.
• Preclinical Studies: Employed in animal model research to understand the pharmacokinetic profile and safety of valproate-related therapies.

Basic Information

Product Name	3-Ketovalproic Acid Sodium Salt
CAS No.	1184991-15-8
Molecular Formula	C8H13NaO3
Molecular Weight	180.18 g/mol
Synonyms	Sodium 3-oxovalproate; 2-Propylpentanoic acid, 3-oxo-, sodium salt; 3-Oxovalproic acid sodium salt; Valproic acid 3-keto metabolite sodium salt; 3-Keto-2-propylpentanoic acid sodium salt; Sodium 3-ketovalproate; 3-Keto VPA sodium salt
EINECS	Contact for details

Quality Control

Our 3-Ketovalproic Acid Sodium Salt is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including identification (IR, NMR), purity assay (HPLC), and control of related substances and residual solvents, to ensure it meets high-purity standards suitable for research and development. A detailed Certificate of Analysis (COA) is provided with every shipment to guarantee traceability, consistency, and compliance with your specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under dry conditions to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Water Content (KF)	≤ 5.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.