Description

5-Benzyl-10-Hydroxy-10,11-Dihydro-5H-Dibenz[B,F]Azepine-D3 is a deuterated analog of a key tricyclic dibenzazepine derivative, offering a stable isotopic label for advanced research and development. This compound is critical for applications requiring precise metabolic and pharmacokinetic studies, where tracking molecular pathways is essential. It is primarily utilized by pharmaceutical R&D teams and analytical laboratories specializing in drug discovery, bioanalytical method development, and forensic toxicology.

Application

• Internal Standard for LC-MS/MS: Serves as a high-purity, isotopically labeled internal standard for the accurate quantification of its non-deuterated counterpart in complex biological matrices.
• Drug Metabolism and Pharmacokinetics (DMPK): Used in mass spectrometry-based studies to investigate the absorption, distribution, metabolism, and excretion (ADME) profiles of pharmaceutical compounds.
• Bioanalytical Method Development: Enables the creation of highly specific and sensitive analytical assays for therapeutic drug monitoring and clinical research.
• Forensic and Clinical Toxicology: Employed as a reference material for the precise identification and quantification of related substances in forensic analysis.
• Pharmaceutical Impurity Profiling: Acts as a reference standard to identify and control potential deuterated impurities in final drug substances.
• Stable Isotope Labeling Studies: Facilitates mechanistic studies in organic chemistry and pharmacology where tracing specific atoms is required.

Basic Information

Product Name	5-Benzyl-10-Hydroxy-10,11-Dihydro-5H-Dibenz[B,F]Azepine-D3
CAS No.	1184982-52-2
Molecular Formula	C21H16D3NO
Molecular Weight	298.40 g/mol
Synonyms	10,11-Dihydro-10-hydroxy-5-(phenylmethyl)-5H-dibenzo[b,f]azepine-d3; 5-Benzyl-10-hydroxy-10,11-dihydro-5H-dibenzo[b,f]azepine-d3; Deuterated 5-Benzyl-10-hydroxy-10,11-dihydro-5H-dibenzazepine; 5-(Phenylmethyl)-10-hydroxy-10,11-dihydro-5H-dibenzo[b,f]azepine-d3; Dibenzo[b,f]azepine-d3, 10,11-dihydro-10-hydroxy-5-(phenylmethyl)-; 5-Benzyl-10-hydroxy-10,11-dihydro-5H-dibenzo[b,f]azepine (deuterated); 5-(Benzyl-d3)-10-hydroxy-10,11-dihydro-5H-dibenzo[b,f]azepine
EINECS	Contact for details

Quality Control

Our 5-Benzyl-10-Hydroxy-10,11-Dihydro-5H-Dibenz[B,F]Azepine-D3 is manufactured under strict quality management systems to ensure the high isotopic purity and chemical integrity required for analytical applications. Each batch is characterized by advanced spectroscopic and chromatographic techniques, including NMR and HPLC-MS, to confirm identity, chemical purity, and deuterium incorporation. Certificates of Analysis (COA) detailing all specifications are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a dry environment. For long-term storage, consider storing under inert atmosphere at -20°C to maximize stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Purity (HPLC)	≥ 98.0%
Deuterium Incorporation (NMR/MS)	≥ 98 atom % D
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.